1. A haplotype in the CCR5 gene promoter was associated with the susceptibility to HIV-1 infection in a northern Chinese population
- Author
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Kaili Wang, Xueyuan Jia, Yang Yu, Yuandong Qiao, Donglin Sun, Yanling Zhao, Chao Shen, Yan Jin, Lidan Xu, Songbin Fu, Xuelong Zhang, Haiming Sun, Jingwei Wang, and Hong Ling
- Subjects
Adult ,China ,Linkage disequilibrium ,Receptors, CCR5 ,Haploview ,HIV Infections ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Cohort Studies ,Young Adult ,Asian People ,Gene Frequency ,Genetics ,Humans ,SNP ,Genetic Predisposition to Disease ,Promoter Regions, Genetic ,Molecular Biology ,Gene ,Genetic Association Studies ,Aged ,Aged, 80 and over ,Acquired Immunodeficiency Syndrome ,Haplotype ,Promoter ,General Medicine ,Middle Aged ,Minor allele frequency ,Genetics, Population ,Haplotypes ,Case-Control Studies ,HIV-1 - Abstract
It has been reported that single nucleotide polymorphisms (SNPs) in the promoter of the CCR5 gene are associated with the risk for HIV-1 infection and AIDS progression. Using resequencing, we performed a systematic survey of 78 HIV-1 seropositive individuals and 70 population-matched healthy control individuals from northern China to investigate SNPs of the CCR5 gene promoter and evaluated their effects on HIV-1 infection and the progression of AIDS. Linkage disequilibrium (LD) plots and haplotypes were generated using Haploview software. The association analyses were statistically compared using the Chi-square test with SPSS13.0 software for Windows. Seven SNPs (58755A>G, 58791C>T, 58934G>T, 59029A>G, 59353C>T, 59402A>G and 59653C>T) in the region of the CCR5 gene promoter were evaluated in this study. Among the seven SNPs, the minor allele frequencies of 58755G and 58791T were less than 2%. The differences in frequencies of the other five SNPs were not significant between case and control cohorts (P > 0.05). In the case cohort, the association between these SNPs and clinical features (CD4+ T-lymphocyte counts and clinical categories) was not significant (P > 0.05); however, there was a significant association between the haplotype GGTAC and susceptibility to HIV-1 infection (P < 0.05), which is not consistent with other reports studied in different populations. The results suggest that the haplotype GGTAC may have a role in the process of HIV-1 infection in the northern Chinese population.
- Published
- 2010