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Your search keyword '"Unger, Kristian"' showing total 3 results
Start Over Author "Unger, Kristian" Journal molecular cancer
3 results on '"Unger, Kristian"'

1. A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer

Author

Schinke, Henrik, Shi, Enxian, Lin, Zhongyang, Quadt, Tanja, Kranz, Gisela, Zhou, Jiefu, Wang, Hongxia, Hess, Julia, Heuer, Steffen, Belka, Claus, Zitzelsberger, Horst, Schumacher, Udo, Genduso, Sandra, Riecken, Kristoffer, Gao, Yujing, Wu, Zhengquan, Reichel, Christoph A., Walz, Christoph, Canis, Martin, Unger, Kristian, Baumeister, Philipp, Pan, Min, and Gires, Olivier

Published
2022
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2. Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells

Author

Di Maro, Gennaro, primary, Salerno, Paolo, additional, Unger, Kristian, additional, Orlandella, Francesca Maria, additional, Monaco, Mario, additional, Chiappetta, Gennaro, additional, Thomas, Gerry, additional, Oczko-Wojciechowska, Malgorzata, additional, Masullo, Mariorosario, additional, Jarzab, Barbara, additional, Santoro, Massimo, additional, and Salvatore, Giuliana, additional

Published
2014
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3. Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells

Author

Gerry Thomas, Kristian Unger, Malgorzata Oczko-Wojciechowska, Paolo Salerno, Gennaro Di Maro, Giuliana Salvatore, Mariorosario Masullo, Mario Monaco, Francesca Maria Orlandella, Massimo Santoro, Barbara Jarzab, Gennaro Chiappetta, DI MARO, Gennaro, Salerno, Paolo, Unger, Kristian, Orlandella, FRANCESCA MARIA, Monaco, Mario, Chiappetta, Gennaro, Thomas, Gerry, Oczko Wojciechowska, Malgorzata, Masullo, Mariorosario, Jarzab, Barbara, Santoro, Massimo, and Salvatore, Giuliana

Subjects
Pathology, Cancer Research, HOMEOSTASIS, Boronic Acid, endocrine system diseases, Survival, Apoptosis, Transcriptome, Bortezomib, Mucoproteins, ENDOPLASMIC-RETICULUM STRESS, Cell Movement, DISULFIDE-ISOMERASE FAMILY, Thyroid cancer, Thyroid Neoplasm, GENE-EXPRESSION, Oncogene Proteins, Gene knockdown, PROLIFERATION, Endoplasmic Reticulum Stress, Boronic Acids, Up-Regulation, Cell Transformation, Neoplastic, Thyroid Cancer, Papillary, Gene Knockdown Techniques, Pyrazines, Molecular Medicine, Life Sciences & Biomedicine, Oxidation-Reduction, Pyrazine, Human, AGR2, medicine.medical_specialty, Biochemistry & Molecular Biology, Cell Survival, Protein Disulfide-Isomerases, Biology, CLASSIFICATION, MECHANISMS, Thyroid carcinoma, LUNG-CANCER, Cell Line, Tumor, medicine, Humans, Migration and invasion, Neoplasm Invasiveness, Thyroid Neoplasms, Endoplasmic Reticulum Stre, PDI FAMILY, Protein Disulfide-Isomerase, Cell Proliferation, Neoplasm Invasivene, Science & Technology, Endoplasmic reticulum, Protein, Research, Carcinoma, Apoptosi, Proteins, medicine.disease, ONCOLOGY, Carcinoma, Papillary, Endoplasmic reticulum stress, Gene Knockdown Technique, Unfolded protein response, Cancer research, Ectopic expression
Abstract

Background Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC). AGR2 is a disulfide isomerase over-expressed in several human carcinomas and recently linked to endoplasmic reticulum (ER) stress. Here, we analyzed the expression of AGR2 in PTC and its functional role. Methods Expression of AGR2 was studied by immunohistochemistry and real time PCR in normal thyroids and in PTC samples. The function of AGR2 was studied by knockdown in PTC cells and by ectopic expression in non-transformed thyroid cells. The role of AGR2 in the ER stress was analyzed upon treatment of cells, expressing or not AGR2, with Bortezomib and analyzing by Western blot the expression levels of GADD153. Results PTC over-expressed AGR2 at mRNA and protein levels. Knockdown of AGR2 in PTC cells induced apoptosis and decreased migration and invasion. Ectopic expression of AGR2 in non-transformed human thyroid cells increased migration and invasion and protected cells from ER stress induced by Bortezomib. Conclusions AGR2 is a novel marker of PTC and plays a role in thyroid cancer cell survival, migration, invasion and protection from ER stress.

Published
2014

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