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• An efficient biohybrid system developed for oxygenation of n-alkanes. • Synergistic combination of MoS 2 -CNT-Eosin-Y with yeast Candida tropicalis shows higher efficiency. • The biohybrid system enables the efficient regeneration of nicotinamide cofactors. • MoS 2 -CNT-Eosin-Y activates the P450 catalytic cycle resulting higher α, ω dicarboxylic acids yield. To date, oxyfunctionalization of saturated hydrocarbons in a selective fashion is a prime challenge in industry. Currently, Inorganic-biohybrid catalysts have shown tremendous potential for sustainable conversion of fine chemicals by integrating light harvesting potential of inorganic materials with metabolic activity of microbes. Herein, we have developed a biohybrid system combining a highly efficient light-harvesting inorganic material MoS 2 -CNT-Eosin-Y and yeast Candida tropicalis (C.tropicalis) for efficient preparation of α, ω- dicarboxylic acid (α, ω-DCA) using saturated n-alkanes. The yeast C.tropicalis harvests photo generated electrons from the illuminated MoS 2 -CNT-Eosin-Y and uses them for the activation of the P450 catalytic cycle. This process enables the efficient regeneration of nicotinamide cofactors (NADH/NAD+) facilitating production of α, ω-DCA. Under irradiation condition the biohybrid catalyst shows 4.01 times higher dodecanedioic acid production compared to that of native yeast strain. Analysis of NADH/NAD+ ratio and alcohol dehydrogenases (ADH) activity clearly indicates that light illumination on MoS 2 -CNT-Eosin-Y/ C.tropicalis promotes regeneration of cofactor during cellular metabolism of C. tropicalis thereby improving the activity of ADH enzyme resulting higher production of α, ω-DCA. The present work opens up a new avenue for the sustainable synthesis of fine chemicals through tailoring of complex biohybrid pathways. [Display omitted] [ABSTRACT FROM AUTHOR]

• Novel biohybrid system for solar assisted CO 2 conversion to chemicals. • Synergistic combination of MOF@ TiO 2 with electroactive microbial system shows higher CO 2 conversion. • Efficient electron transfer stimulate Wood-Ljungdahl pathway of electro active microbes. • Well-organized charge transfer from ZTC@TiO 2 to a microbe resulted a high methanol yield. Recently, photosynthetic biohybrid systems are emerged as efficient catalytic materials having advantages of the light-harvesting ability of semiconductors and the catalytic efficiency of biological system. In this context, a stable visible light active Zn-metal organic framework (ZTC) functionalized with TiO 2 (ZTC@TiO 2) was synthesized, and synergistically integrated with an electroactive microbial (EAB) system for efficient CO 2 reduction under visible-light illumination. The resultant bio-hybrid shows remarkably higher CO 2 reduction under visible light irradiation as compared to independent ZTC@TiO 2 and microbe system. Under optimized condition, the bioinorganic hybrid (EAB-ZTC@TiO 2) shows a CO 2 conversion to acetic acid and methanol with a higher selectivity towards methanol. The improved photocatalytic CO 2 conversion and selectivity towards methanol is ascribed to a well-organized donor-acceptor interfacial charge transfer from ZTC@TiO 2 to a microbe, which effectively activates the Wood-Ljungdahl pathway of microbes, thereby improving the CO 2 reduction efficiency. [Display omitted] [ABSTRACT FROM AUTHOR]