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Your search keyword '"Blobel, Gerd A."' showing total 13 results
Start Over Author "Blobel, Gerd A." Journal molecular cell
13 results on '"Blobel, Gerd A."'

1. Gene silencing dynamics are modulated by transiently active regulatory elements

Author

Vermunt, Marit W., primary, Luan, Jing, additional, Zhang, Zhe, additional, Thrasher, A. Josephine, additional, Huang, Anran, additional, Saari, Megan S., additional, Khandros, Eugene, additional, Beagrie, Robert A., additional, Zhang, Shiping, additional, Vemulamada, Pranay, additional, Brilleman, Matilda, additional, Lee, Kiwon, additional, Yano, Jennifer A., additional, Giardine, Belinda M., additional, Keller, Cheryl A., additional, Hardison, Ross C., additional, and Blobel, Gerd A., additional

Published
2023
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2. ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency

Author

Cao, Zhendong, primary, Budinich, Krista A., additional, Huang, Hua, additional, Ren, Diqiu, additional, Lu, Bin, additional, Zhang, Zhen, additional, Chen, Qingzhou, additional, Zhou, Yeqiao, additional, Huang, Yu-Han, additional, Alikarami‬, Fatemeh, additional, Kingsley, Molly C., additional, Lenard, Alexandra K., additional, Wakabayashi, Aoi, additional, Khandros, Eugene, additional, Bailis, Will, additional, Qi, Jun, additional, Carroll, Martin P., additional, Blobel, Gerd A., additional, Faryabi, Robert B., additional, Bernt, Kathrin M., additional, Berger, Shelley L., additional, and Shi, Junwei, additional

Published
2021
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3. Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML

Author

Riedel, Simone S., primary, Lu, Congcong, additional, Xie, Hongbo M., additional, Nestler, Kevin, additional, Vermunt, Marit W., additional, Lenard, Alexandra, additional, Bennett, Laura, additional, Speck, Nancy A., additional, Hanamura, Ichiro, additional, Lessard, Julie A., additional, Blobel, Gerd A., additional, Garcia, Benjamin A., additional, and Bernt, Kathrin M., additional

Published
2021
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4. ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Author

Lan, Xianjiang, primary, Ren, Ren, additional, Feng, Ruopeng, additional, Ly, Lana C., additional, Lan, Yemin, additional, Zhang, Zhe, additional, Aboreden, Nicholas, additional, Qin, Kunhua, additional, Horton, John R., additional, Grevet, Jeremy D., additional, Mayuranathan, Thiyagaraj, additional, Abdulmalik, Osheiza, additional, Keller, Cheryl A., additional, Giardine, Belinda, additional, Hardison, Ross C., additional, Crossley, Merlin, additional, Weiss, Mitchell J., additional, Cheng, Xiaodong, additional, Shi, Junwei, additional, and Blobel, Gerd A., additional

Published
2021
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6. The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries

Author

Hsu, Sarah C., primary, Gilgenast, Thomas G., additional, Bartman, Caroline R., additional, Edwards, Christopher R., additional, Stonestrom, Aaron J., additional, Huang, Peng, additional, Emerson, Daniel J., additional, Evans, Perry, additional, Werner, Michael T., additional, Keller, Cheryl A., additional, Giardine, Belinda, additional, Hardison, Ross C., additional, Raj, Arjun, additional, Phillips-Cremins, Jennifer E., additional, and Blobel, Gerd A., additional

Published
2017
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7. Unlinking an lncRNA from Its Associated cis Element

Author

Paralkar, Vikram R., primary, Taborda, Cristian C., additional, Huang, Peng, additional, Yao, Yu, additional, Kossenkov, Andrew V., additional, Prasad, Rishi, additional, Luan, Jing, additional, Davies, James O.J., additional, Hughes, Jim R., additional, Hardison, Ross C., additional, Blobel, Gerd A., additional, and Weiss, Mitchell J., additional

Published
2016
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13. Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

Author

Vakoc CR, Letting DL, Gheldof N, Sawado T, Bender MA, Groudine M, Weiss MJ, Dekker J, and Blobel GA

Subjects
Animals, Base Sequence, Binding Sites genetics, Carrier Proteins genetics, Cell Line, DNA chemistry, DNA genetics, DNA metabolism, DNA-Binding Proteins genetics, Enhancer Elements, Genetic, Erythroid-Specific DNA-Binding Factors, GATA1 Transcription Factor, Humans, Locus Control Region, Mice, Mice, Mutant Strains, Nuclear Proteins genetics, Nucleic Acid Conformation, Promoter Regions, Genetic, Protein Binding, RNA Polymerase II genetics, RNA Polymerase II metabolism, Transcription Factors genetics, Carrier Proteins metabolism, DNA-Binding Proteins metabolism, Genes, Regulator, Globins genetics, Nuclear Proteins metabolism, Transcription Factors metabolism
Abstract

Recent evidence suggests that long-range enhancers and gene promoters are in close proximity, which might reflect the formation of chromatin loops. Here, we examined the mechanism for DNA looping at the beta-globin locus. By using chromosome conformation capture (3C), we show that the hematopoietic transcription factor GATA-1 and its cofactor FOG-1 are required for the physical interaction between the beta-globin locus control region (LCR) and the beta-major globin promoter. Kinetic studies reveal that GATA-1-induced loop formation correlates with the onset of beta-globin transcription and occurs independently of new protein synthesis. GATA-1 occupies the beta-major globin promoter normally in fetal liver erythroblasts from mice lacking the LCR, suggesting that GATA-1 binding to the promoter and LCR are independent events that occur prior to loop formation. Together, these data demonstrate that GATA-1 and FOG-1 are essential anchors for a tissue-specific chromatin loop, providing general insights into long-range enhancer function.

Published
2005
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