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Your search keyword '"Bourboulia, Dimitra"' showing total 3 results
Start Over Author "Bourboulia, Dimitra" Journal molecular cell
3 results on '"Bourboulia, Dimitra"'

1. Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors

Author

Mollapour, Mehdi, primary, Bourboulia, Dimitra, additional, Beebe, Kristin, additional, Woodford, Mark R., additional, Polier, Sigrun, additional, Hoang, Anthony, additional, Chelluri, Raju, additional, Li, Yu, additional, Guo, Ailan, additional, Lee, Min-Jung, additional, Fotooh-Abadi, Elham, additional, Khan, Sahar, additional, Prince, Thomas, additional, Miyajima, Naoto, additional, Yoshida, Soichiro, additional, Tsutsumi, Shinji, additional, Xu, Wanping, additional, Panaretou, Barry, additional, Stetler-Stevenson, William G., additional, Bratslavsky, Gennady, additional, Trepel, Jane B., additional, Prodromou, Chrisostomos, additional, and Neckers, Len, additional

Published
2014
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2. Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

Author

Mollapour, Mehdi, primary, Tsutsumi, Shinji, additional, Donnelly, Alison C., additional, Beebe, Kristin, additional, Tokita, Mari J., additional, Lee, Min-Jung, additional, Lee, Sunmin, additional, Morra, Giulia, additional, Bourboulia, Dimitra, additional, Scroggins, Bradley T., additional, Colombo, Giorgio, additional, Blagg, Brian S., additional, Panaretou, Barry, additional, Stetler-Stevenson, William G., additional, Trepel, Jane B., additional, Piper, Peter W., additional, Prodromou, Chrisostomos, additional, Pearl, Laurence H., additional, and Neckers, Len, additional

Published
2010
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3. Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

Author

Mollapour, Mehdi, Tsutsumi, Shinji, Donnelly, Alison C., Beebe, Kristin, Tokita, Mari J., Lee, Min-Jung, Lee, Sunmin, Morra, Giulia, Bourboulia, Dimitra, Scroggins, Bradley T., Colombo, Giorgio, Blagg, Brian S., Panaretou, Barry, Stetler-Stevenson, William G., Trepel, Jane B., Piper, Peter W., Prodromou, Chrisostomos, Pearl, Laurence H., and Neckers, Len

Subjects
*TYROSINE, *PHOSPHORYLATION, *HEAT shock proteins, *SACCHAROMYCES, *PROTEIN-tyrosine kinases, *CHEMICAL inhibitors, *MOLECULAR chaperones, *ADENOSINE triphosphatase, *POST-translational modification
Abstract

Summary: Saccharomyces WEE1 (Swe1), the only “true” tyrosine kinase in budding yeast, is an Hsp90 client protein. Here we show that Swe1Wee1 phosphorylates a conserved tyrosine residue (Y24 in yeast Hsp90 and Y38 in human Hsp90α) in the N domain of Hsp90. Phosphorylation is cell-cycle associated and modulates the ability of Hsp90 to chaperone a selected clientele, including v-Src and several other kinases. Nonphosphorylatable mutants have normal ATPase activity, support yeast viability, and productively chaperone the Hsp90 client glucocorticoid receptor. Deletion of SWE1 in yeast increases Hsp90 binding to its inhibitor geldanamycin, and pharmacologic inhibition/silencing of Wee1 sensitizes cancer cells to Hsp90 inhibitor-induced apoptosis. These findings demonstrate that Hsp90 chaperoning of distinct client proteins is differentially regulated by specific posttranslational modification of a unique subcellular pool of the chaperone, and they provide a strategy to increase the cellular potency of Hsp90 inhibitors. [Copyright &y& Elsevier]

Published
2010
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