1. A FACT about macroH2A removal in immune gene activation.
- Author
-
Meers O and Buschbeck M
- Subjects
- Humans, Immunity, Innate genetics, Animals, Transcriptional Activation, Histones metabolism, Histones genetics, Epigenesis, Genetic
- Abstract
Histone variants contribute to epigenetic regulation in development and disease but require the chaperone machinery for correct deposition. In this issue of Molecular Cell, Ji et al.
1 explain how the chaperone complex FACT removes the histone variant macroH2A1.2 and demonstrate its importance for gene activation in innate immune cells., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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