1. MicroRNA-29: A Crucial Player in Fibrotic Disease.
- Author
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Deng Z, He Y, Yang X, Shi H, Shi A, Lu L, and He L
- Subjects
- Gene Expression Regulation, Humans, Keloid genetics, Kidney pathology, Liver Cirrhosis genetics, Myocardium pathology, Pulmonary Fibrosis genetics, Scleroderma, Systemic genetics, Fibrosis genetics, MicroRNAs physiology
- Abstract
Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-29 (miR-29) can play pivotal roles in the regulation of a variety of organ fibrosis, including cardiac fibrosis, hepatic fibrosis, lung fibrosis, systemic sclerosis, and keloid. In this review, we outline the structure, expression, and regulation of miR-29 as well as its role in fibrotic diseases.
- Published
- 2017
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