Search

Your search keyword '"Histopathologic response"' showing total 2 results
Start Over Descriptor "Histopathologic response" Journal molecular imaging and biology
2 results on '"Histopathologic response"'

2. Sequential FDG-PET/CT after neoadjuvant chemotherapy is a predictor of histopathologic response in patients with head and neck squamous cell carcinoma

Author

Shinya Hori, Hiroshi Yamazaki, Yasushi Naito, Yu Usami, Masahiro Kikuchi, Keizo Fujiwara, Shogo Shinohara, Tsunemichi Adachi, Yukihiro Imai, Yosuke Tona, and Yuji Nakamoto

Subjects
Male, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Standardized uptake value, Fluorodeoxyglucose F18, medicine, Carcinoma, Humans, Radiology, Nuclear Medicine and imaging, Histopathologic response, Aged, Chemotherapy, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Middle Aged, medicine.disease, Head and neck squamous-cell carcinoma, Magnetic Resonance Imaging, Neoadjuvant Therapy, Oncology, ROC Curve, Positron emission tomography, Head and Neck Neoplasms, Positron-Emission Tomography, Carcinoma, Squamous Cell, Female, Tomography, Radiology, business, Tomography, X-Ray Computed
Abstract

To evaluate whether 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) more accurately predicts the histopathologic response to neoadjuvant chemotherapy (NAC) than magnetic resonance imaging (MRI) in patients with head and neck squamous cell carcinoma (HNSCC).Sixteen patients with HNSCC underwent FDG-PET/CT and MRI scans before and after one cycle of NAC, followed by surgical resection. The 26 surgically resected specimens of the 16 patients were analyzed. Decreases in maximum standardized uptake value (SUV(max)) or in tumor maximum size (diameter(max)) were calculated, and their accuracies for the prediction of histopathologic response were evaluated.In histopathologic responders (n = 7), percent decreases in SUV(max) were significantly higher (P 0.001) than in non-responders (n = 19). Applying a cut-off point of 55.5%, the histopathologic response could be predicted with a sensitivity and specificity of 86% and 95%, respectively.FDG-PET/CT can predict histopathologic NAC responses with higher accuracy than MRI in HNSCC patients.

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results