1. Clinical Translation of [
- Author
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Catarina, Xavier, Anneleen, Blykers, Damya, Laoui, Evangelia, Bolli, Ilse, Vaneyken, Jessica, Bridoux, Henri, Baudhuin, Geert, Raes, Hendrik, Everaert, Kiavash, Movahedi, Jo A, Van Ginderachter, Nick, Devoogdt, Vicky, Caveliers, Tony, Lahoutte, and Marleen, Keyaerts
- Subjects
Carcinogenesis ,Macrophages ,Gallium Radioisotopes ,Receptors, Cell Surface ,Single-Domain Antibodies ,Mice, Inbred C57BL ,Translational Research, Biomedical ,Heterocyclic Compounds, 1-Ring ,Mannose-Binding Lectins ,Positron Emission Tomography Computed Tomography ,Animals ,Humans ,Female ,Lectins, C-Type ,Tissue Distribution ,Radiometry ,Mannose Receptor ,Protein Binding - Abstract
Macrophage mannose receptor (MMR, CD206) expressing tumor-associated macrophages (TAM) are protumorigenic and was reported to negatively impact therapy responsiveness and is associated with higher chances of tumor relapse following multiple treatment regimens in preclinical tumor models. Since the distribution of immune cells within the tumor is often heterogeneous, sampling "errors" using tissue biopsies will occur. In order to overcome this limitation, we propose positron emission tomography (PET)/X-ray computed tomography (CT) imaging usingCross-reactive anti-MMR-sdAb was produced according to good manufacturing practice (GMP) and conjugated to p-SCN-Bn-NOTA bifunctional chelator for[Preclinical validation of [
- Published
- 2019