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3. Letter to the editor concerning the paper: Boltjes A, Op den Brouw ML, Biesta PJ, et al. Assessment of the effect of ribavirin on myeloid and plasmacytoid dendritic cells during interferon-based therapy of chronic hepatitis B patients [Molecular Immunology 53(1/2) (2013) 72-78]

Author

Shilpa Choksi, Ioannis Pachiadakis, Georgios Ilonidis, Ioannis Goulis, and Evangelos Akriviadis

Subjects
Male, Letter to the editor, Myeloid, Immunology, Antiviral Agents, Polyethylene Glycols, chemistry.chemical_compound, Molecular Immunology, Hepatitis B, Chronic, Chronic hepatitis, Interferon, Ribavirin, medicine, Humans, Molecular Biology, business.industry, Interferon-alpha, Dendritic Cells, Hepatitis B, medicine.disease, Virology, medicine.anatomical_structure, chemistry, Female, business, medicine.drug
Published
2013

4. Opinion paper: Stimulation of complement amplification or activation of the alternative pathway of complement?

Author

Sandra Fumia, Velia Alaia, Hans U. Lutz, and Claudia Schurtenberger

Subjects
Immunology, Complement Pathway, Alternative, chemical and pharmacologic phenomena, Stimulation, Complement System Proteins, Biology, C3-convertase, Complement system, Complement (complexity), Immune system, Alternative complement pathway, Animals, Humans, Molecular Biology, Neuroscience
Abstract

In this opinion paper, we suggest that the scheme of the complement system should be redrawn in order to better illustrate its potencies. This can be achieved by putting the amplification loop of the alternative complement pathway at the center of the complement system. This arrangement emphasizes that C3b molecules, generated by any pathway, can stimulate complement amplification. Furthermore, it allows one to differentiate between this type of stimulation of amplification and that driven by those immune complexes that capture dimeric C3b molecules, which are more potent C3 convertase precursors than C3b. Schemes similar to the one drawn may help to better illustrate the interplay of the pathways and convey a clearer comprehension of the mechanics of the complement system.

Published
2007