1. IL-8 promotes proliferation and inhibition of apoptosis via STAT3/AKT/NF-κB pathway in prostate cancer
- Author
-
Quancheng Feng, Ying Zang, Guoying Zhang, Tingting Qian, Yidi Guo, Feng Cai, and Lianzheng Lv
- Subjects
Oncology ,Male ,STAT3 Transcription Factor ,0301 basic medicine ,medicine.medical_specialty ,Cancer Research ,Apoptosis ,Traditional Chinese medicine ,Biochemistry ,Metastasis ,chemistry.chemical_compound ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Internal medicine ,Cell Line, Tumor ,Genetics ,medicine ,Humans ,STAT3 ,Molecular Biology ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Cell Proliferation ,biology ,Oncogene ,business.industry ,Chemistry ,Interleukin-8 ,NF-kappa B ,Prostatic Neoplasms ,Cancer ,NF-κB ,medicine.disease ,Molecular medicine ,030104 developmental biology ,030220 oncology & carcinogenesis ,biology.protein ,Cancer research ,STAT protein ,Molecular Medicine ,Signal transduction ,business ,Corrigendum ,Proto-Oncogene Proteins c-akt ,Signal Transduction - Abstract
Interleukin-8 (IL-8) possesses tumorigenic and proangiogenic properties, and is overexpressed in many human cancer types. However, only few studies have demonstrated the mechanisms of action of IL‑8 regarding the ability to promote proliferation and to inhibit apoptosis in prostate cancer. Here, the aim of the present study was to investigate the effects of IL‑8 on the prostate cancer cell line and determine possible mechanisms underlying its effect. In this study, IL‑8 was shown to be significantly upregulated in prostate cancer compared with paired normal control tissues. The data showed that IL‑8 exhibits direct oncogenicity, which significantly induced cell proliferation, invasion and attenuated apoptosis in prostate cancer cells via signal transducer and activator of transcription 3/protein kinase B/nuclear factor‑κB signaling pathways. In conclusion, modulation of IL‑8 expression or its associated signaling pathway may provide a novel working mechanism of IL‑8 in prostate cancer, and a promising strategy for controlling the progression and metastasis of prostate cancer.
- Published
- 2017