Search

Your search keyword '"Shulian Li"' showing total 4 results
Start Over Author "Shulian Li" Journal molecular medicine reports
4 results on '"Shulian Li"'

1. Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen-transformed MEF cells

Author

Yuanfang Ma, Shulian Li, Qiying Jiang, Zhi Zhang, Yanzhong Hu, and Zhaoyang Wang

Subjects
p53, Male, Vascular Endothelial Growth Factor A, Cancer Research, Lung Neoplasms, Skin Neoplasms, Angiogenesis, Fibrosarcoma, phosphorylated retinoblastoma protein, Antigens, CD34, Simian virus 40, medicine.disease_cause, Retinoblastoma Protein, Biochemistry, Gene Knockout Techniques, Mice, Heat Shock Transcription Factors, Phosphorylation, simian virus 40/T antigen, Antigens, Viral, Tumor, HSF1, Heat-Shock Proteins, Cell Line, Transformed, Mice, Inbred BALB C, biology, Retinoblastoma protein, Articles, Neoplasm Proteins, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Vascular endothelial growth factor A, heat shock factor 1, Oncology, Molecular Medicine, Signal Transduction, Mice, Nude, Heat shock protein, von Willebrand Factor, Genetics, medicine, Animals, Molecular Biology, Cell Proliferation, Cell growth, fungi, Fibroblasts, Embryo, Mammalian, Heat shock factor, tumorigenesis, biology.protein, Cancer research, Tumor Suppressor Protein p53, Carcinogenesis, Neoplasm Transplantation, Molecular Chaperones, Transcription Factors
Abstract

Heat shock factor 1 (Hsf1) serves an important role in regulating the proliferation of human tumor cell lines in vitro and tissue specific tumorigenesis in certain mouse models. However, its role in viral‑oncogenesis remains to be fully elucidated. In the current study, the role of Hsf1 in fibroblastoma derived from simian virus 40/T antigen (SV40/TAG)‑transformed mouse embryonic fibroblast (MEF) cell lines was investigated. Knockout of Hsf1 inhibited MEF cell proliferation in vitro and fibroblastoma growth and metastasis to the lungs in vivo in nude mice. Knockout of Hsf1 increased the protein expression levels of p53 and phosphorylated retinoblastoma protein (pRb), however reduced the expression of heat shock protein 25 (Hsp25) in addition to the expression of the angiogenesis markers vascular endothelial growth factor, cluster of differentiation 34 and factor VIII related antigen. Furthermore, immunoprecipitation indicated that knockout of Hsf1 inhibited the association between SV40/TAG and p53 or pRb. These data suggest that Hsf1 is involved in the regulation of SV40/TAG‑derived fibroblastoma growth and metastasis by modulating the association between SV40/TAG and tumor suppressor p53 and pRb. The current study provides further evidence that Hsf1 may be a novel therapeutic target in the treatment of cancer.

Published
2015
Full Text
View/download PDF

2. Upregulation of heat shock factor 1 transcription activity is associated with hepatocellular carcinoma progression

Author

Guangchao Liu, Zhengshun Song, Zheng Dong, Xiaoming Qin, Shulian Li, Qiang Lou, Yanzhong Hu, Yaqin Zhang, Wanli Ma, Yuanfang Ma, Jun Zhang, Teng Fei, and Xiukun Cui

Subjects
Male, Cancer Research, Carcinoma, Hepatocellular, Gene Expression, retinoblastoma protein, medicine.disease_cause, Biochemistry, Carcinoembryonic antigen, Heat Shock Transcription Factors, Biomarkers, Tumor, Genetics, medicine, Humans, HSP70 Heat-Shock Proteins, HSF1, Molecular Biology, Cell Proliferation, Oncogene, biology, phosphorylation, Liver Neoplasms, fungi, Retinoblastoma protein, Hep G2 Cells, Articles, hepatocellular carcinoma, Middle Aged, Cell cycle, medicine.disease, Molecular biology, digestive system diseases, Up-Regulation, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Heat shock factor, heat shock factor 1, Oncology, Hepatocellular carcinoma, Disease Progression, Cancer research, biology.protein, Molecular Medicine, Female, Carcinogenesis, Transcription Factors
Abstract

Heat shock factor 1 (HSF1) is associated with tissue-specific tumorigenesis in a number of mouse models, and has been used a as prognostic marker of cancer types, including breast and prostatic cancer. However, its role in human hepatocellular carcinoma (HCC) is not well understood. Using immunoblotting and immunohistochemical staining, it was identified that HSF1 and its serine (S) 326 phosphorylation, a biomarker of HSF1 activation, are significantly upregulated in human HCC tissues and HCC cell lines compared with their normal counterparts. Cohort analyses indicated that upregulation of the expression of HSF1 and its phospho-S326 is significantly correlated with HCC progression, invasion and patient survival prognosis (P

Published
2014
Full Text
View/download PDF

3. Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen-transformed MEF cells.

Author

QIYING JIANG, ZHI ZHANG, SHULIAN LI, ZHAOYANG WANG, YUANFANG MA, and YANZHONG HU

Subjects
HEAT shock factors, SV40 (Virus), ANTIGENS, NEOPLASTIC cell transformation, PHOSPHORYLATION, RETINOBLASTOMA protein
Abstract

Heat shock factor 1 (Hsf1) serves an important role in regulating the proliferation of human tumor cell lines in vitro and tissue specific tumorigenesis in certain mouse models. However, its role in viral-oncogenesis remains to be fully elucidated. In the current study, the role of Hsf1 in fibroblastoma derived from simian virus 40/T antigen (SV40/TAG)-transformed mouse embryonic fibroblast (MEF) cell lines was investigated. Knockout of Hsf1 inhibited MEF cell proliferation in vitro and fibroblastoma growth and metastasis to the lungs in vivo in nude mice. Knockout of Hsf1 increased the protein expression levels of p53 and phosphorylated retinoblastoma protein (pRb), however reduced the expression of heat shock protein 25 (Hsp25) in addition to the expression of the angiogenesis markers vascular endothelial growth factor, cluster of differentiation 34 and factor VIII related antigen. Furthermore, immunoprecipitation indicated that knockout of Hsf1 inhibited the association between SV40/TAG and p53 or pRb. These data suggest that Hsf1 is involved in the regulation of SV40/TAG-derived fibroblastoma growth and metastasis by modulating the association between SV40/TAG and tumor suppressor p53 and pRb. The current study provides further evidence that Hsf1 may be a novel therapeutic target in the treatment of cancer. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

4. Upregulation of heat shock factor 1 transcription activity is associated with hepatocellular carcinoma progression.

Author

SHULIAN LI, WANLI MA, TENG FEI, QIANG LOU, YAQIN ZHANG, XIUKUN CUI, XIAOMING QIN, JUN ZHANG, GUANGCHAO LIU, ZHENG DONG, YUANFANG MA, ZHENGSHUN SONG, and YANZHONG HU

Subjects
*HEAT shock factors, *LIVER cancer, *NEOPLASTIC cell transformation, *CANCER invasiveness, *IMMUNOBLOTTING, *IMMUNOSTAINING
Abstract

Heat shock factor 1 (HSF1) is associated with tissue-specific tumorigenesis in a number of mouse models, and has been used a as prognostic marker of cancer types, including breast and prostatic cancer. However, its role in human hepatocellular carcinoma (HCC) is not well understood. Using immunoblotting and immunohistochemical staining, it was identified that HSF1 and its serine (S) 326 phosphorylation, a biomarker of HSF1 activation, are significantly upregulated in human HCC tissues and HCC cell lines compared with their normal counterparts. Cohort analyses indicated that upregulation of the expression of HSF1 and its phospho-S326 is significantly correlated with HCC progression, invasion and patient survival prognosis (P<0.001); however, not in the presence of a hepatitis B virus infection and the expression of alpha-fetoprotein and carcinoembryonic antigen. Knockdown of HSF1 with shRNA induced the protein expression of tumor suppressor retinoblastoma protein, resulting in attenuated plc/prf5 cell growth and colony formation in vitro. Taken together, these data markedly support that HSF1 is a potential prognostic marker and therapeutic target for the treatment of HCC. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results