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Start Over Author "Su-Mi Lee" Journal molecular medicine reports
3 results on '"Su-Mi Lee"'

1. Primary bile acid activates Egr‑1 expression through the MAPK signaling pathway in gastric cancer

Author

Su-Mi Lee, Moon Park, Seon-Young Park, Yoo-Duk Choi, Jin Chung, Dong Kim, Young Jung, and Hyun Kim

Subjects
Adult, Aged, 80 and over, Male, Mitogen-Activated Protein Kinase 1, Cancer Research, Mitogen-Activated Protein Kinase 3, MAP Kinase Signaling System, Oncogenes, Middle Aged, Biochemistry, Up-Regulation, Bile Acids and Salts, Young Adult, Oncology, Stomach Neoplasms, Cell Line, Tumor, Genetics, Molecular Medicine, Humans, Female, Molecular Biology, Aged, Early Growth Response Protein 1
Abstract

Bile acids have been linked to pathomechanism and prognosis in various types of cancers. The present study aimed to investigate the effect of bile acids on the molecular change in gastric epithelial cancer cells and to evaluate gastric bile acid concentration in patients with early gastric cancer (EGC). Human gastric cancer cells (AGS and NCI‑N87 cell lines) were treated with several bile acid types to determine their effect on molecular changes in the cells. Gastric levels of individual bile acids were measured (primary unconjugated or conjugated bile acids and secondary bile acids) in 39 participants (20 controls and 19 patients with EGC). Exposing gastric epithelial cancer cells to primary bile acids

Published
2021

2. Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells

Author

Hyun-Chul Kim, Ji Young Kim, Sung-Kyu Choi, Su-Mi Lee, Jong-Sun Rew, Sung-Bum Cho, Chung-Hwan Jun, Seon-Young Park, Young Eun Joo, and Park Changhwan

Subjects
Cancer Research, p38 mitogen-activated protein kinases, Cell, Apoptosis, Biology, p38 Mitogen-Activated Protein Kinases, Biochemistry, chemistry.chemical_compound, Stomach Neoplasms, Cell Line, Tumor, Genetics, medicine, Humans, MTT assay, Phosphorylation, Molecular Biology, Cell Proliferation, Oncogene, Caspase 3, Mitochondria, Cell biology, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Proto-Oncogene Proteins c-bcl-2, Oncology, chemistry, Cell culture, Capsaicin, Cancer cell, Cancer research, Molecular Medicine, lipids (amino acids, peptides, and proteins), Signal Transduction
Abstract

Capsaicin is known to have tumor suppressive effects. However, the molecular mechanisms and targets of capsaicin involved in exerting anticancer activity are complex and remain to be clarified. The aim of the current study was to investigate the effects of capsaicin on human gastric cancer cells (AGS cells) and demonstrate that capsaicin induced apoptosis in AGS cells. Results of the MTT assay and flow cytometry revealed that capsaicin potentially inhibited the proliferation of AGS cells and induced apoptosis in vitro in a dose-dependent manner. Cleaved caspase-3 was increased and Bcl-2 was reduced by treatment with capsaicin in AGS cells. Capsaicin treatment decreased the expression of phosphorylated ERK 1/2, p38 MAPK or JNK in AGS cells. The results of this study suggest that capsaicin may serve as an anti-tumorigenic agent in human gastric cancer.

Published
2013

3. Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells.

Author

SEON-YOUNG PARK, JI-YOUNG KIM, SU-MI LEE, CHUNG-HWAN JUN, SUNG-BUM CHO, CHANG-HWAN PARK, YOUNG EUN JOO, HYUN-SOO KIM, SUNG-KYU CHOI, and JONG-SUN REW

Subjects
CAPSAICIN, APOPTOSIS, MITOGEN-activated protein kinases, GASTRIC mucosa, CANCER cells, CANCER
Abstract

Capsaicin is known to have tumor suppressive effects. However, the molecular mechanisms and targets of capsaicin involved in exerting anticancer activity are complex and remain to be clarified. The aim of the current study was to investigate the effects of capsaicin on human gastric cancer cells (AGS cells) and demonstrate that capsaicin induced apoptosis in AGS cells. Results of the MTT assay and flow cytometry revealed that capsaicin potentially inhibited the proliferation of AGS cells and induced apoptosis in vitro in a dose-dependent manner. Cleaved caspase-3 was increased and Bcl-2 was reduced by treatment with capsaicin in AGS cells. Capsaicin treatment decreased the expression of phosphorylated ERK 1/2, p38 MAPK or JNK in AGS cells. The results of this study suggest that capsaicin may serve as an anti-tumorigenic agent in human gastric cancer. [ABSTRACT FROM AUTHOR]

Published
2014
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