1. Rice Bran Lipidome Identifies Novel Phospholipids, Glycolipids and Oxylipins with Roles in Lipid Metabolism of Hypercholesterolemic Children
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Millena Cristina Barros Santos, Nathalie Barouh, Valérie Lullien‐Pellerin, Valérie Micard, Pierre Villeneuve, Bingqing Zhou, Camille Oger, Claire Vigor, Thierry Durand, Mariana Simões Larraz Ferreira, Claire Bourlieu‐Lacanal, Elizabeth P. Ryan, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Institut Agro Montpellier, Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), Colorado State University [Fort Collins] (CSU), National Institute of Food and Agriculture (NIFA, 2016-67001-24538, Ryan, the Foundation for Research Support of State of Rio de Janeiro (FAPERJ) (26/010.100988/2018, 26/202/709-2018, 26/201.848/2019, 26/200.171/2022), National Council for Scientific and Technological Development (CNPq) (427116/2018-0, 310343/2019-4), UNIRIO, Coordination for Improvement of Personnel with Higher Education (CAPES) (financial code 001), Montpellier University of Scholarly Excellence (MUSE)., and ANR-16-IDEX-0006,MUSE,MUSE(2016)
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[SDV.IDA]Life Sciences [q-bio]/Food engineering ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Food Science ,Biotechnology - Abstract
The purpose of the study is to characterize the chemical diversity in Rice bran (RB) lipidome and determine whether daily RB consumption for 4 weeks may modulate plasma lipid profiles in children.Untargeted and targeted lipidomics via ultra-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-MS/MS) were applied to identify bioactive RB lipids from a collection of 17 rice varieties. To determine the impact of RB (Calrose-USA variety) supplementation on plasma lipid profile, a secondary analysis of plasma lipidome was conducted on data recorded in a clinical study (NCT01911390, n = 18 moderately hypercholesterolemic children) before and after 4 weeks of dietary intervention (15 g/d) with a control or RB supplemented snack. Untargeted lipidomic revealed 118 lipids as the core of lipidome across all 17 varieties among which phospholipids were abundant and oxylipins present. Phytoprostanes and phytofurans were quantified and characterized. Lipidome analysis of the children plasma following RB consumption revealed the presence of novel polar lipids and oxylipins alongside putative modulations in endocannabinoids associated with RB consumption.The investigation of novel polar lipids, oxylipins, phytoprostanes, and phytofurans in RB extracts provides support for new health-promoting properties especially interesting for people at risk for cardiometabolic disease. This article is protected by copyright. All rights reserved.
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- 2022
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