Search

Your search keyword '"Haojun Chen"' showing total 4 results
Start Over Author "Haojun Chen" Journal molecular pharmaceutics
4 results on '"Haojun Chen"'

1. PD-L1-Targeted Radionuclide Therapy Combined with αPD-L1 Antibody Immunotherapy Synergistically Improves the Antitumor Effect

Author

Xuejun Wen, Xueyuan Zeng, Xingxing Cheng, Xinying Zeng, Jia Liu, Yiren Zhang, Yesen Li, Haojun Chen, Jinxiong Huang, Zhide Guo, Xiaoyuan Chen, and Xianzhong Zhang

Subjects
Programmed Cell Death 1 Receptor, Pharmaceutical Science, Receptors, Death Domain, Ligands, Antibodies, Iodine Radioisotopes, Mice, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Immunologic Factors, Molecular Medicine, Immunotherapy, Immune Checkpoint Inhibitors
Abstract

Immune checkpoint blockers (ICBs) targeting programmed death receptor 1 (PD-1) ligand 1 (PD-L1) for immunotherapy have radically reformed oncology. It is of great significance to enhance the response rate of ICB in cancer patients. Here, a radioiodinated anti-PD-L1 antibody (

Published
2022
Full Text
View/download PDF

3. Development of Fibroblast Activation Protein Inhibitor-Based Dimeric Radiotracers with Improved Tumor Retention and Antitumor Efficacy

Author

Liang Zhao, Jianhao Chen, Yizhen Pang, Jianyang Fang, Kaili Fu, Lingxin Meng, Xianzhong Zhang, Zhide Guo, Hua Wu, Long Sun, Guoqiang Su, Qin Lin, and Haojun Chen

Subjects
Cancer-Associated Fibroblasts, Neoplasms, Positron Emission Tomography Computed Tomography, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Animals, Humans, Membrane Proteins, Gallium Radioisotopes, Tissue Distribution, Phosphates
Abstract

Fibroblast activation protein (FAP), a fundamental component of the tumor stroma, is overexpressed in cancer-associated fibroblasts (CAFs). As a promising theranostic probe, we evaluated whether the FAP inhibitor (FAPI) dimer (DOTA-2P[FAPI]

Published
2022

4. Dual Targeting of Integrin α

Author

Lanlin, Yao, Yesen, Li, Haojun, Chen, Xuejun, Wen, Yizhen, Pang, Zijun, Chen, Zhide, Guo, Xianzhong, Zhang, Hua, Wu, and Wei, Guo

Subjects
Cell Line, Tumor, Positron-Emission Tomography, Humans, Breast Neoplasms, Female, Gallium Radioisotopes, Tissue Distribution, Integrin alphaVbeta3, Oligopeptides, Neuropilin-1
Abstract

The receptors neuropilin-1 (NRP-1) and integrin α

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results