5 results on '"Salim, Al-Babili"'
Search Results
2. An alternative, zeaxanthin epoxidase-independent abscisic acid biosynthetic pathway in plants
- Author
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Kun-Peng Jia, Angel R. de Lera, Lamis Berqdar, Shawkat Ali, Jianing Mi, Hajime Ohyanagi, Salim Al-Babili, Gianfranco Diretto, Juan Moreno, Aparna Balakrishna, Takashi Gojobori, Alessia Fiore, Claudio Martínez, and Abdugaffor Ablazov
- Subjects
Genotype ,Zeaxanthin epoxidase ,Arabidopsis ,Plant Science ,Genes, Plant ,chemistry.chemical_compound ,Biosynthesis ,Gene Expression Regulation, Plant ,Arabidopsis thaliana ,Molecular Biology ,Abscisic acid ,biology ,organic chemicals ,fungi ,Genetic Variation ,food and beverages ,biology.organism_classification ,Biosynthetic Pathways ,Xanthoxin ,Biochemistry ,chemistry ,Apocarotenoid ,biology.protein ,Oxidoreductases ,Abscisic Acid ,Violaxanthin - Abstract
Abscisic acid (ABA) is an important carotenoid-derived phytohormone that plays essential roles in plant response to biotic and abiotic stresses as well as in various physiological and developmental processes. In Arabidopsis, ABA biosynthesis starts with the epoxidation of zeaxanthin by the ABA DEFICIENT 1 (ABA1) enzyme, leading to epoxycarotenoids, e.g., violaxanthin. The oxidative cleavage of 9-cis-epoxycarotenoids, a key regulatory step catalyzed by 9-CIS-EPOXYCAROTENOID DIOXYGENASE, forms xanthoxin that is converted in further reactions mediated by ABA DEFICIENT 2 (ABA2), ABA DEFICIENT 3 (ABA3), and ABSCISIC ALDEHYDE OXIDASE 3 (AAO3) into ABA. By combining genetic and biochemical approaches, we unravel here an ABA1-independent ABA biosynthetic pathway starting upstream of zeaxanthin. We identified the carotenoid cleavage products, i.e., apocarotenoids, β-apo-11-carotenal, 9-cis-β-apo-11-carotenal, 3-OH-β-apo-11-carotenal, and 9-cis-3-OH-β-apo-11-carotenal as intermediates of this ABA1-independent ABA biosynthetic pathway. Using labeled compounds, we showed that β-apo-11-carotenal, 9-cis-β-apo-11-carotenal, and 3-OH-β-apo-11-carotenal are successively converted into 9-cis-3-OH-β-apo-11-carotenal, xanthoxin, and finally into ABA in both Arabidopsis and rice. When applied to Arabidopsis, these β-apo-11-carotenoids exert ABA biological functions, such as maintaining seed dormancy and inducing the expression of ABA-responsive genes. Indeed, the transcriptomic analysis revealed a high overlap of differentially expressed genes regulated by β-apo-11-carotenoids and ABA, but also suggested that these compounds exert ABA-independent regulatory activities. Taken together, our study identifies a biological function for the common plant metabolites β-apo-11-carotenoids, extends our knowledge about ABA biosynthesis and provides new insights into plant apocarotenoid metabolic networks.
- Published
- 2022
3. 3-Hydroxycarlactone, a Novel Product of the Strigolactone Biosynthesis Core Pathway
- Author
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Boubacar Amadou Kountche, Kohki Akiyama, Narumi Mori, Lina Baz, Muhammad Jamil, Kun-Peng Jia, Xiujie Guo, Salim Al-Babili, Martina Vermathen, Jianing Mi, and Aparna Balakrishna
- Subjects
0106 biological sciences ,0301 basic medicine ,Magnetic Resonance Spectroscopy ,Arabidopsis ,Germination ,Striga ,Plant Science ,Biology ,01 natural sciences ,Dioxygenases ,03 medical and health sciences ,Lactones ,Plant Growth Regulators ,Tobacco ,Escherichia coli ,Molecular Biology ,Plant Proteins ,Arabidopsis Proteins ,Peas ,Oryza ,Strigolactone biosynthesis ,Recombinant Proteins ,Cell biology ,030104 developmental biology ,Product (mathematics) ,010606 plant biology & botany - Published
- 2021
4. Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications
- Author
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Randa Alhassan Yahya Zarban, Ikuo Takahashi, Angel R. de Lera, Pei-Yu Lin, Salim Al-Babili, Mara Novero, Jian You Wang, Muhammad Jamil, Luisa Lanfranco, Tsuyoshi Ota, Tadao Asami, Valentina Fiorilli, Boubacar Amadou Kountche, Claudio Martínez, and Paola Bonfante
- Subjects
0106 biological sciences ,0301 basic medicine ,Research Report ,Parasitic plant ,Mutant ,Strigolactone ,Rice growth ,Plant Science ,Striga ,Transcript level ,01 natural sciences ,03 medical and health sciences ,Lactones ,Structure-Activity Relationship ,root parasitic plants ,strigolactone ,Molecular Biology ,zaxinone mimics ,biology ,business.industry ,zaxinone ,Molecular Mimicry ,Oryza ,biology.organism_classification ,Biotechnology ,apocarotenoids ,030104 developmental biology ,Agriculture ,Apocarotenoid ,business ,Agrochemicals ,Heterocyclic Compounds, 3-Ring ,010606 plant biology & botany - Abstract
Zaxinone is an apocarotenoid regulatory metabolite required for normal rice growth and development. In addition, zaxinone has a large application potential in agriculture, due to its growth-promoting activity and capability to alleviate infestation by the root parasitic plant Striga through decreasing strigolactone (SL) production. However, zaxinone is poorly accessible to the scientific community because of its laborious organic synthesis that impedes its further investigation and utilization. In this study, we developed easy-to-synthesize and highly efficient mimics of zaxinone (MiZax). We performed a structure–activity relationship study using a series of apocarotenoids distinguished from zaxinone by different structural features. Using the obtained results, we designed several phenyl-based compounds synthesized with a high-yield through a simple method. Activity tests showed that MiZax3 and MiZax5 exert zaxinone activity in rescuing root growth of a zaxinone-deficient rice mutant, promoting growth, and reducing SL content in roots and root exudates of wild-type plants. Moreover, these compounds were at least as efficient as zaxinone in suppressing transcript level of SL biosynthesis genes and in alleviating Striga infestation under greenhouse conditions, and did not negatively impact mycorrhization. Taken together, MiZax are a promising tool for elucidating zaxinone biology and investigating rice development, and suitable candidates for combating Striga and increasing crop growth., Zaxinone is an apocarotenoid growth regulator and plant hormone candidate that promotes rice growth and acts as a negative regulator of strigolactone biosynthesis. Wang et al. performed a structure–activity relationship study and used obtained results to generate a series of easy-to-synthesize mimics of zaxinone (MiZax) that were as efficient as zaxinone in promoting rice growth, repressing strigolactone biosynthesis, and alleviating infestation by the parasitic weed Striga. The developed MiZax will significantly support zaxinone research and are promising candidates for agricultural applications.
- Published
- 2020
5. To Color or to Decolor: that Is the Question
- Author
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Jianing Mi and Salim Al-Babili
- Subjects
0106 biological sciences ,0301 basic medicine ,Base line ,Library science ,Plant Science ,Flowers ,Pigments, Biological ,Biology ,01 natural sciences ,03 medical and health sciences ,030104 developmental biology ,Work (electrical) ,Fruit ,Molecular Biology ,010606 plant biology & botany ,Plant Proteins - Abstract
FUNDING: This work was supported by base line funding and a Competitive Research Grant (CRG2017) given to Salim Al-Babili by the King Abdullah University of Science and Technology (KAUST).
- Published
- 2019
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