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Your search keyword '"Meyer-Lindenberg, Andreas"' showing total 12 results
Start Over Author "Meyer-Lindenberg, Andreas" Journal molecular psychiatry
12 results on '"Meyer-Lindenberg, Andreas"'

1. A primer on the use of machine learning to distil knowledge from data in biological psychiatry

Author

Quinn, Thomas P., Hess, Jonathan L., Marshe, Victoria S., Barnett, Michelle M., Hauschild, Anne-Christin, Maciukiewicz, Malgorzata, Elsheikh, Samar S. M., Men, Xiaoyu, Schwarz, Emanuel, Trakadis, Yannis J., Breen, Michael S., Barnett, Eric J., Zhang-James, Yanli, Ahsen, Mehmet Eren, Cao, Han, Chen, Junfang, Hou, Jiahui, Salekin, Asif, Lin, Ping-I, Nicodemus, Kristin K., Meyer-Lindenberg, Andreas, Bichindaritz, Isabelle, Faraone, Stephen V., Cairns, Murray J., Pandey, Gaurav, Müller, Daniel J., and Glatt, Stephen J.

Published
2024
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2. Towards a youth mental health paradigm: a perspective and roadmap

Author

Uhlhaas, Peter J., Davey, Christopher G., Mehta, Urvakhsh Meherwan, Shah, Jai, Torous, John, Allen, Nicholas B., Avenevoli, Shelli, Bella-Awusah, Tolulope, Chanen, Andrew, Chen, Eric Y. H., Correll, Christoph U., Do, Kim Q., Fisher, Helen L., Frangou, Sophia, Hickie, Ian B., Keshavan, Matcheri S., Konrad, Kerstin, Lee, Francis S., Liu, Cindy H., Luna, Beatriz, McGorry, Patrick D., Meyer-Lindenberg, Andreas, Nordentoft, Merete, Öngür, Dost, Patton, George C., Paus, Tomáš, Reininghaus, Ulrich, Sawa, Akira, Schoenbaum, Michael, Schumann, Gunter, Srihari, Vinod H., Susser, Ezra, Verma, Swapna K., Woo, T. Wilson, Yang, Lawrence H., Yung, Alison R., and Wood, Stephen J.

Published
2023
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3. A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

Author

Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M, Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T, Blier, Pierre, Cleare, Anthony J, Cowen, Philip J, Dinan, Timothy G, Fagiolini, Andrea, Ferrier, I Nicol, Hegerl, Ulrich, Krystal, Andrew D, Leboyer, Marion, McAllister-Williams, R Hamish, McIntyre, Roger S, Meyer-Lindenberg, Andreas, Miller, Andrew H, Nemeroff, Charles B, Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda WJH, Schatzberg, Alan F, Shelton, Richard C, Yatham, Lakshmi N, Young, Allan H, Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni-Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M, Hoogendijk, Witte JG, Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E, van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J Antoni, Savitz, Adam J, and Pariante, Carmine M

Subjects
Clinical Trials and Supportive Activities, Depression, Clinical Research, Mental Health, Brain Disorders, Serious Mental Illness, Major Depressive Disorder, Good Health and Well Being, Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Humans, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. We reviewed the literature and brought together a group of international experts (including clinicians, academics, researchers, employees of pharmaceutical companies, regulatory bodies representatives, and one person with lived experience) to evaluate the state-of-the-art and main controversies regarding the current classification. We then provided recommendations on how to design clinical trials, and on how to guide research in unmet needs and knowledge gaps. This report will feed into one of the main objectives of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project, to design a protocol for platform trials of new medications for TRD/PRD.

Published
2022

4. Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits

Author

O’Leary, Aet, Fernàndez-Castillo, Noèlia, Gan, Gabriela, Yang, Yunbo, Yotova, Anna Y., Kranz, Thorsten M., Grünewald, Lena, Freudenberg, Florian, Antón-Galindo, Ester, Cabana-Domínguez, Judit, Harneit, Anais, Schweiger, Janina I., Schwarz, Kristina, Ma, Ren, Chen, Junfang, Schwarz, Emanuel, Rietschel, Marcella, Tost, Heike, Meyer-Lindenberg, Andreas, Pané-Farré, Christiane A., Kircher, Tilo, Hamm, Alfons O., Burguera, Demian, Mota, Nina Roth, Franke, Barbara, Schweiger, Susann, Winter, Jennifer, Heinz, Andreas, Erk, Susanne, Romanczuk-Seiferth, Nina, Walter, Henrik, Ströhle, Andreas, Fehm, Lydia, Fydrich, Thomas, Lueken, Ulrike, Weber, Heike, Lang, Thomas, Gerlach, Alexander L., Nöthen, Markus M., Alpers, Georg W., Arolt, Volker, Witt, Stephanie, Richter, Jan, Straube, Benjamin, Cormand, Bru, Slattery, David A., and Reif, Andreas

Published
2022
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8. Identifying multimodal signatures underlying the somatic comorbidity of psychosis: the COMMITMENT roadmap

Author

Schwarz, Emanuel, Alnæs, Dag, Andreassen, Ole A., Cao, Han, Chen, Junfang, Degenhardt, Franziska, Doncevic, Daria, Dwyer, Dominic, Eils, Roland, Erdmann, Jeanette, Herrmann, Carl, Hofmann-Apitius, Martin, Kaufmann, Tobias, Koutsouleris, Nikolaos, Kodamullil, Alpha T., Khuntia, Adyasha, Mucha, Sören, Nöthen, Markus M., Paul, Riya, Pedersen, Mads L., Quintero, Andres, Schunkert, Heribert, Sharma, Ashwini, Tost, Heike, Westlye, Lars T., Zhang, Youcheng, and Meyer-Lindenberg, Andreas

Published
2021
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9. A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

Author

Sforzini, Luca, primary, Worrell, Courtney, additional, Kose, Melisa, additional, Anderson, Ian M., additional, Aouizerate, Bruno, additional, Arolt, Volker, additional, Bauer, Michael, additional, Baune, Bernhard T., additional, Blier, Pierre, additional, Cleare, Anthony J., additional, Cowen, Philip J., additional, Dinan, Timothy G., additional, Fagiolini, Andrea, additional, Ferrier, I. Nicol, additional, Hegerl, Ulrich, additional, Krystal, Andrew D., additional, Leboyer, Marion, additional, McAllister-Williams, R. Hamish, additional, McIntyre, Roger S., additional, Meyer-Lindenberg, Andreas, additional, Miller, Andrew H., additional, Nemeroff, Charles B., additional, Normann, Claus, additional, Nutt, David, additional, Pallanti, Stefano, additional, Pani, Luca, additional, Penninx, Brenda W. J. H., additional, Schatzberg, Alan F., additional, Shelton, Richard C., additional, Yatham, Lakshmi N., additional, Young, Allan H., additional, Zahn, Roland, additional, Aislaitner, Georgios, additional, Butlen-Ducuing, Florence, additional, Fletcher, Christine, additional, Haberkamp, Marion, additional, Laughren, Thomas, additional, Mäntylä, Fanni-Laura, additional, Schruers, Koen, additional, Thomson, Andrew, additional, Arteaga-Henríquez, Gara, additional, Benedetti, Francesco, additional, Cash-Gibson, Lucinda, additional, Chae, Woo Ri, additional, De Smedt, Heidi, additional, Gold, Stefan M., additional, Hoogendijk, Witte J. G., additional, Mondragón, Valeria Jordán, additional, Maron, Eduard, additional, Martynowicz, Jadwiga, additional, Melloni, Elisa, additional, Otte, Christian, additional, Perez-Fuentes, Gabriela, additional, Poletti, Sara, additional, Schmidt, Mark E., additional, van de Ketterij, Edwin, additional, Woo, Katherine, additional, Flossbach, Yanina, additional, Ramos-Quiroga, J. Antoni, additional, Savitz, Adam J., additional, and Pariante, Carmine M., additional

Published
2021
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10. Identifying multimodal signatures underlying the somatic comorbidity of psychosis: the COMMITMENT roadmap

Author

Schwarz, Emanuel, primary, Alnæs, Dag, additional, Andreassen, Ole A., additional, Cao, Han, additional, Chen, Junfang, additional, Degenhardt, Franziska, additional, Doncevic, Daria, additional, Dwyer, Dominic, additional, Eils, Roland, additional, Erdmann, Jeanette, additional, Herrmann, Carl, additional, Hofmann-Apitius, Martin, additional, Kaufmann, Tobias, additional, Koutsouleris, Nikolaos, additional, Kodamullil, Alpha T., additional, Khuntia, Adyasha, additional, Mucha, Sören, additional, Nöthen, Markus M., additional, Paul, Riya, additional, Pedersen, Mads L., additional, Quintero, Andres, additional, Schunkert, Heribert, additional, Sharma, Ashwini, additional, Tost, Heike, additional, Westlye, Lars T., additional, Zhang, Youcheng, additional, and Meyer-Lindenberg, Andreas, additional

Published
2020
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12. Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits.

Author

O'Leary A, Fernàndez-Castillo N, Gan G, Yang Y, Yotova AY, Kranz TM, Grünewald L, Freudenberg F, Antón-Galindo E, Cabana-Domínguez J, Harneit A, Schweiger JI, Schwarz K, Ma R, Chen J, Schwarz E, Rietschel M, Tost H, Meyer-Lindenberg A, Pané-Farré CA, Kircher T, Hamm AO, Burguera D, Mota NR, Franke B, Schweiger S, Winter J, Heinz A, Erk S, Romanczuk-Seiferth N, Walter H, Ströhle A, Fehm L, Fydrich T, Lueken U, Weber H, Lang T, Gerlach AL, Nöthen MM, Alpers GW, Arolt V, Witt S, Richter J, Straube B, Cormand B, Slattery DA, and Reif A

Subjects
Animals, Mice, Humans, Genome-Wide Association Study, Mice, Knockout, RNA Splicing Factors genetics, Autism Spectrum Disorder genetics, Depressive Disorder, Major genetics, Mental Disorders genetics
Abstract

Common variation in the gene encoding the neuron-specific RNA splicing factor RNA Binding Fox-1 Homolog 1 (RBFOX1) has been identified as a risk factor for several psychiatric conditions, and rare genetic variants have been found causal for autism spectrum disorder (ASD). Here, we explored the genetic landscape of RBFOX1 more deeply, integrating evidence from existing and new human studies as well as studies in Rbfox1 knockout mice. Mining existing data from large-scale studies of human common genetic variants, we confirmed gene-based and genome-wide association of RBFOX1 with risk tolerance, major depressive disorder and schizophrenia. Data on six mental disorders revealed copy number losses and gains to be more frequent in ASD cases than in controls. Consistently, RBFOX1 expression appeared decreased in post-mortem frontal and temporal cortices of individuals with ASD and prefrontal cortex of individuals with schizophrenia. Brain-functional MRI studies demonstrated that carriers of a common RBFOX1 variant, rs6500744, displayed increased neural reactivity to emotional stimuli, reduced prefrontal processing during cognitive control, and enhanced fear expression after fear conditioning, going along with increased avoidance behaviour. Investigating Rbfox1 neuron-specific knockout mice allowed us to further specify the role of this gene in behaviour. The model was characterised by pronounced hyperactivity, stereotyped behaviour, impairments in fear acquisition and extinction, reduced social interest, and lack of aggression; it provides excellent construct and face validity as an animal model of ASD. In conclusion, convergent translational evidence shows that common variants in RBFOX1 are associated with a broad spectrum of psychiatric traits and disorders, while rare genetic variation seems to expose to early-onset neurodevelopmental psychiatric disorders with and without developmental delay like ASD, in particular. Studying the pleiotropic nature of RBFOX1 can profoundly enhance our understanding of mental disorder vulnerability., (© 2022. The Author(s).)

Published
2022
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