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Start Over Author "Nicholson, Jeremy K." Journal molecular systems biology
7 results on '"Nicholson, Jeremy K."'

2. Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model

Author

Martin, Francois‐Pierre J, primary, Wang, Yulan, additional, Sprenger, Norbert, additional, Yap, Ivan K S, additional, Lundstedt, Torbjörn, additional, Lek, Per, additional, Rezzi, Serge, additional, Ramadan, Ziad, additional, van Bladeren, Peter, additional, Fay, Laurent B, additional, Kochhar, Sunil, additional, Lindon, John C, additional, Holmes, Elaine, additional, and Nicholson, Jeremy K, additional

Published
2008
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3. Top‐down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model

Author

Martin, Francois‐Pierre J, primary, Wang, Yulan, additional, Sprenger, Norbert, additional, Yap, Ivan K S, additional, Rezzi, Serge, additional, Ramadan, Ziad, additional, Peré‐Trepat, Emma, additional, Rochat, Florence, additional, Cherbut, Christine, additional, van Bladeren, Peter, additional, Fay, Laurent B, additional, Kochhar, Sunil, additional, Lindon, John C, additional, Holmes, Elaine, additional, and Nicholson, Jeremy K, additional

Published
2008
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5. A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse model

Author

Martin, François‐Pierre J, primary, Dumas, Marc‐Emmanuel, additional, Wang, Yulan, additional, Legido‐Quigley, Cristina, additional, Yap, Ivan K S, additional, Tang, Huiru, additional, Zirah, Séverine, additional, Murphy, Gerard M, additional, Cloarec, Olivier, additional, Lindon, John C, additional, Sprenger, Norbert, additional, Fay, Laurent B, additional, Kochhar, Sunil, additional, van Bladeren, Peter, additional, Holmes, Elaine, additional, and Nicholson, Jeremy K, additional

Published
2007
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7. Human metabolic profiles are stably controlled by genetic and environmental variation.

Author

Nicholson, George, Rantalainen, Mattias, Maher, Anthony D, Li, Jia V, Malmodin, Daniel, Ahmadi, Kourosh R, Faber, Johan H, Hallgrímsdóttir, Ingileif B, Barrett, Amy, Toft, Henrik, Krestyaninova, Maria, Viksna, Juris, Neogi, Sudeshna Guha, Dumas, Marc‐Emmanuel, Sarkans, Ugis, Silverman, Bernard W, Donnelly, Peter, Nicholson, Jeremy K, Allen, Maxine, and Zondervan, Krina T

Abstract

1H Nuclear Magnetic Resonance spectroscopy (1H NMR) is increasingly used to measure metabolite concentrations in sets of biological samples for top‐down systems biology and molecular epidemiology. For such purposes, knowledge of the sources of human variation in metabolite concentrations is valuable, but currently sparse. We conducted and analysed a study to create such a resource. In our unique design, identical and non‐identical twin pairs donated plasma and urine samples longitudinally. We acquired 1H NMR spectra on the samples, and statistically decomposed variation in metabolite concentration into familial (genetic and common‐environmental), individual‐environmental, and longitudinally unstable components. We estimate that stable variation, comprising familial and individual‐environmental factors, accounts on average for 60% (plasma) and 47% (urine) of biological variation in 1H NMR‐detectable metabolite concentrations. Clinically predictive metabolic variation is likely nested within this stable component, so our results have implications for the effective design of biomarker‐discovery studies. We provide a power‐calculation method which reveals that sample sizes of a few thousand should offer sufficient statistical precision to detect 1H NMR‐based biomarkers quantifying predisposition to disease. [ABSTRACT FROM AUTHOR]

Published
2011
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