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Your search keyword '"Hernan Nicolas Lemus"' showing total 2 results
Start Over Author "Hernan Nicolas Lemus" Journal molecular therapy: methods & clinical development
2 results on '"Hernan Nicolas Lemus"'

1. An Assay that Predicts In Vivo Efficacy for DNA Aptamers that Stimulate Remyelination in a Mouse Model of Multiple Sclerosis

Author

Robin M. Heider, John A. Smestad, Hernan Nicolas Lemus, Brandon Wilbanks, Arthur E. Warrington, Justin P. Peters, Moses Rodriguez, and L. James Maher, III

Subjects
Genetics, QH426-470, Cytology, QH573-671
Abstract

Multiple sclerosis (MS) is a debilitating disease for which regenerative therapies are sought. We have previously described human antibodies and DNA aptamer-streptavidin conjugates that promote remyelination after systemic injection into mice infected by Theiler’s murine encephalomyelitis virus. Here, we report an in vitro assay of myelin binding with results that correlate with remyelination outcome in vivo, as shown for data from a set of DNA aptamer complexes of different size and formulation. This in vitro assay will be valuable for future screening of MS regenerative therapies targeting remyelination. Keywords: multiple sclerosis, aptamer, myelin, oligodendrocyte, regeneration

Published
2018
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2. An Assay that Predicts In Vivo Efficacy for DNA Aptamers that Stimulate Remyelination in a Mouse Model of Multiple Sclerosis

Author

L. James Maher, John A. Smestad, Moses Rodriguez, Arthur E. Warrington, Hernan Nicolas Lemus, Robin M. Heider, Brandon Wilbanks, and Justin P. Peters

Subjects
0301 basic medicine, lcsh:QH426-470, Aptamer, 03 medical and health sciences, Myelin, 0302 clinical medicine, In vivo, Genetics, medicine, Remyelination, lcsh:QH573-671, Molecular Biology, biology, business.industry, lcsh:Cytology, Multiple sclerosis, Regeneration (biology), medicine.disease, Oligodendrocyte, lcsh:Genetics, 030104 developmental biology, medicine.anatomical_structure, Cancer research, biology.protein, Molecular Medicine, Antibody, business, 030217 neurology & neurosurgery
Abstract

Multiple sclerosis (MS) is a debilitating disease for which regenerative therapies are sought. We have previously described human antibodies and DNA aptamer-streptavidin conjugates that promote remyelination after systemic injection into mice infected by Theiler’s murine encephalomyelitis virus. Here, we report an in vitro assay of myelin binding with results that correlate with remyelination outcome in vivo, as shown for data from a set of DNA aptamer complexes of different size and formulation. This in vitro assay will be valuable for future screening of MS regenerative therapies targeting remyelination. Keywords: multiple sclerosis, aptamer, myelin, oligodendrocyte, regeneration

Published
2018

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