1. 999. Mature Effector Immunological Synapses Forming SMAC Mediate Clearance of Virally Infected Astrocytes from the Brain In Vivo.
- Author
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Barcia, Carlos, Thomas, Clare, Curtin, James F., King, Gwendalyn D., Wawrowsky, Kolja, Candolfi, Marianela, Xiong, Wei-Dong, Chunyan, Liu, Kroeger, Kurt, Boyer, Olivier, Kupiec-Weglinski, Jerzy, Klatzmann, David, Castro, Maria G., and Lowenstein, Pedro R.
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ASTROCYTES , *NEURAL transmission , *CELL communication , *CELL adhesion molecules , *T cells , *LYMPHOCYTES - Abstract
Immunological synapses are the essential anatomical structure that channel information exchanges between T-APC during the priming and effector phases of T cells' function, and during NK- target cell interactions. The hallmark of immunological synapses established by T cells is the formation of the supramolecular activation clusters (SMAC), in which adhesion molecules such as LFA-1 segregate to the peripheral domain of the immunological synapse (p-SMAC), which surrounds the TCR-rich or central SMAC (c-SMAC). The inability so far to detect SMAC formation in vivo has cast doubts on their functional relevance. Herein we demonstrate that the in vivo formation of SMAC at immunological synapses between effector CD8+ T-cells and target cells precedes and mediates clearance of virally infected brain astrocytes.Molecular Therapy (2006) 13, S385–S385; doi: 10.1016/j.ymthe.2006.08.1092 [ABSTRACT FROM AUTHOR]
- Published
- 2006
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