Search

Your search keyword '"Fujiwara, Toshiyoshi"' showing total 11 results
Start Over Author "Fujiwara, Toshiyoshi" Journal molecular therapy
11 results on '"Fujiwara, Toshiyoshi"'

2. Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus

Author

Yano, Shuya, Miwa, Shinji, Kishimoto, Hiroyuki, Toneri, Makoto, Hiroshima, Yukihiko, Yamamoto, Mako, Bouvet, Michael, Urata, Yasuo, Tazawa, Hiroshi, Kagawa, Shunsuke, Fujiwara, Toshiyoshi, and Hoffman, Robert M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Brain Cancer, Brain Disorders, Cancer, Neurosciences, Adenoviridae, Animals, Cell Line, Tumor, Disease Models, Animal, Disease-Free Survival, Fluorescence, Glioblastoma, Green Fluorescent Proteins, Humans, Mice, Mice, Nude, Neoplasm Recurrence, Local, Optical Imaging, Biological Sciences, Technology, Medical and Health Sciences, Biotechnology, Genetics, Clinical sciences, Medical biotechnology
Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.

Published
2015

3. Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

Author

Kanaya, Nobuhiko, primary, Kuroda, Shinji, additional, Kakiuchi, Yoshihiko, additional, Kumon, Kento, additional, Tsumura, Tomoko, additional, Hashimoto, Masashi, additional, Morihiro, Toshiaki, additional, Kubota, Tetsushi, additional, Aoyama, Katsuyuki, additional, Kikuchi, Satoru, additional, Nishizaki, Masahiko, additional, Kagawa, Shunsuke, additional, Tazawa, Hiroshi, additional, Mizuguchi, Hiroyuki, additional, Urata, Yasuo, additional, and Fujiwara, Toshiyoshi, additional

Published
2020
Full Text
View/download PDF

4. Biological Ablation of Sentinel Lymph Node Metastasis in Submucosally Invaded Early Gastrointestinal Cancer

Author

Kikuchi, Satoru, primary, Kishimoto, Hiroyuki, additional, Tazawa, Hiroshi, additional, Hashimoto, Yuuri, additional, Kuroda, Shinji, additional, Nishizaki, Masahiko, additional, Nagasaka, Takeshi, additional, Shirakawa, Yasuhiro, additional, Kagawa, Shunsuke, additional, Urata, Yasuo, additional, Hoffman, Robert M, additional, and Fujiwara, Toshiyoshi, additional

Published
2015
Full Text
View/download PDF

5. A Phase I Study of Telomerase-specific Replication Competent Oncolytic Adenovirus (Telomelysin) for Various Solid Tumors

Author

Nemunaitis, John, primary, Tong, Alex W, additional, Nemunaitis, Michael, additional, Senzer, Neil, additional, Phadke, Anagha P, additional, Bedell, Cynthia, additional, Adams, Ned, additional, Zhang, Yu-An, additional, Maples, Phillip B, additional, Chen, Salina, additional, Pappen, Beena, additional, Burke, James, additional, Ichimaru, Daiju, additional, Urata, Yasuo, additional, and Fujiwara, Toshiyoshi, additional

Published
2010
Full Text
View/download PDF

7. 639. In Vivo Imaging of Lymph Node Metastasis with Telomerase-Specific Replication-Competent Adenovirus Containing Green Fluorescent Protein Gene

Author

Kojima, Toru, primary, Kishimoto, Hiroyuki, additional, Watanabe, Yuichi, additional, Kagawa, Shunsuke, additional, Teraishi, Fuminori, additional, Hioki, Masayoshi, additional, Ikeda, Yoshihiro, additional, Sakai, Ryo, additional, Urata, Yasuo, additional, Tanaka, Noriaki, additional, and Fujiwara, Toshiyoshi, additional

Published
2006
Full Text
View/download PDF

10. 298. Combination Effect of Telomerase-Specific Replication-Competent Adenovirus (Telomelysin, OBP-301) and p53 Gene Therapy in Human Non- Small Cell Lung and Colon Cancer Cells

Author

Sakai, Ryo, primary, Teraishi, Fuminori, additional, Kojima, Toru, additional, Ikeda, Yoshihiro, additional, Hioki, Masayoshi, additional, Fujiwara, Toshiya, additional, Uno, Futoshi, additional, Kagawa, Shunsuke, additional, Hashimoto, Yuuri, additional, Watanabe, Yuichi, additional, Urata, Yasuo, additional, Tanaka, Noriaki, additional, and Fujiwara, Toshiyoshi, additional

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results