1. Effect of Culture Conditions on Metabolite Production of Xylaria sp.
- Author
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Hongqi Zhang, Zhangshuang Deng, Zhiyong Guo, Yan Peng, Nianyu Huang, Haibo He, Xuan Tu, and Kun Zou
- Subjects
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XYLARIA , *NATURAL products , *CYTOCHALASINS , *PLANT metabolites , *CELL-mediated cytotoxicity - Abstract
Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 1-5 to six new α-pyrone derivatives, xylapyrones A-F (compounds 6-11), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 1-3 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC50 values ranging from 25 to 63 μM and compounds 4-11 were found to be inactive, with ICY50 values >100 μM. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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