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11 results on '"Alharbi Metab"'

2. Evaluation of Antimicrobial, Anticholinesterase Potential of Indole Derivatives and Unexpectedly Synthesized Novel Benzodiazine: Characterization, DFT and Hirshfeld Charge Analysis

Author

Raza, Abdul Rauf, primary, Rubab, Syeda Laila, additional, Ashfaq, Muhammad, additional, Altaf, Yasir, additional, Tahir, Muhammad Nawaz, additional, Rehman, Muhammad Fayyaz ur, additional, Aziz, Tariq, additional, Alharbi, Metab, additional, and Alasmari, Abdullah F., additional

Published
2023
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3. Biosynthesis and Mathematical Interpretation of Zero-Valent Iron NPs Using Nigella sativa Seed Tincture for Indemnification of Carcinogenic Metals Present in Industrial Effluents

Author

Naveed, Muhammad, primary, Makhdoom, Syeda Izma, additional, Rehman, Shafiq ur, additional, Aziz, Tariq, additional, Bashir, Farzana, additional, Ali, Urooj, additional, Alharbi, Metab, additional, Alshammari, Abdulrahman, additional, and Alasmari, Abdullah F., additional

Published
2023
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5. HPLC, FTIR and GC-MS Analyses of Thymus vulgaris Phytochemicals Executing In Vitro and In Vivo Biological Activities and Effects on COX-1, COX-2 and Gastric Cancer Genes Computationally

Author

Saleem, Ayesha, primary, Afzal, Muhammad, additional, Naveed, Muhammad, additional, Makhdoom, Syeda Izma, additional, Mazhar, Modasrah, additional, Aziz, Tariq, additional, Khan, Ayaz Ali, additional, Kamal, Zul, additional, Shahzad, Muhammad, additional, Alharbi, Metab, additional, and Alshammari, Abdulrahman, additional

Published
2022
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7. Effect of Natural Adenylcyclase/cAMP/CREB Signalling Activator Forskolin against Intra-Striatal 6-OHDA-Lesioned Parkinson’s Rats: Preventing Mitochondrial, Motor and Histopathological Defects

Author

Alharbi, Metab, primary, Alshammari, Abdulrahman, additional, Kaur, Gurpreet, additional, Kalra, Sanjeev, additional, Mehan, Sidharth, additional, Suri, Manisha, additional, Chhabra, Swesha, additional, Kumar, Nitish, additional, Alanazi, Wael A., additional, Alshanwani, Aliah R., additional, AL-Ghamdi, Abdullah Hamed, additional, Narula, Acharan S., additional, and Kalfin, Reni, additional

Published
2022
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9. In Silico Analysis and Functional Characterization of Antimicrobial and Insecticidal Vicilin from Moth Bean (Vigna aconitifolia (Jacq.) Marechal) Seeds

Author

Ateeq, Muhammad, primary, Adeel, Muhammad Muzammal, additional, Kanwal, Ayesha, additional, Tahir ul Qamar, Muhammad, additional, Saeed, Ahsan, additional, Khaliq, Binish, additional, Saeed, Qamar, additional, Atiq, Muhammad Nauman, additional, Bilal, Muhammad, additional, Alharbi, Metab, additional, Alshammari, Abdulrahman, additional, and Akrem, Ahmed, additional

Published
2022
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11. Integrating Pharmacological and Computational Approaches for the Phytochemical Analysis of Syzygium cumini and Its Anti-Diabetic Potential.

Author

Rashid, Fatima, Javaid, Anam, Mahmood-ur-Rahman, Ashfaq, Usman Ali, Sufyan, Muhammad, Alshammari, Abdulrahman, Alharbi, Metab, Nisar, Muhammad Atif, and Khurshid, Mohsin

Subjects
ALPHA-glucosidases, GALLIC acid, PROTEIN-ligand interactions, SYZYGIUM, BINDING energy, HYDROGEN bonding, INSULIN
Abstract

Diabetes mellitus (DM) is a metabolic disease caused by improper insulin secretion leading to hyperglycemia. Syzygium cumini has excellent therapeutic properties due to its high levels of phytochemicals. The current research aimed to evaluate the anti-diabetic potential of S. cumini plant's seeds and the top two phytochemicals (kaempferol and gallic acid) were selected for further analysis. These phytochemicals were selected via computational tools and evaluated for α-Glucosidase inhibitory activity via enzymatic assay. Gallic acid (IC50 0.37 µM) and kaempferol (IC50 0.87 µM) have shown a stronger α-glucosidase inhibitory capacity than acarbose (5.26 µM). In addition, these phytochemicals demonstrated the highest binding energy, hydrogen bonding, protein–ligand interaction and the best MD simulation results at 100 ns compared to acarbose. Furthermore, the ADMET properties of gallic acid and kaempferol also fulfilled the safety criteria. Thus, it was concluded that S. cumini could potentially be used to treat DM. The potential bioactive molecules identified in this study (kaempferol and gallic acid) may be used as lead drugs against diabetes. [ABSTRACT FROM AUTHOR]

Published
2022
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