Search

Your search keyword '"Berti, Federico"' showing total 9 results
Start Over Author "Berti, Federico" Journal molecules
9 results on '"Berti, Federico"'

5. Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters.

Author

Bnedetti, Fabio, Berti, Federico, Fanfoni, Lidia, Garbo, Michele, Regini, Giorgia, and Felluga, Fulvia

Abstract

The four-step conversion of a series of N-Boc-protected L-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elimination of related -acetoxysulfones. The overall transformation takes place under mild conditions, with good yields, and without loss of stereochemical integrity, being in this respect superior to the conventional Julia reaction of -amino aldehydes. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

6. Oleocanthal Quantification Using 1 H NMR Spectroscopy and Polyphenols HPLC Analysis of Olive Oil from the Bianchera/Belica Cultivar.

Author

Starec, Martina, Calabretti, Antonella, Berti, Federico, Forzato, Cristina, Papetti, Adele, and Fabiani, Roberto

Subjects
PLANT polyphenols, HIGH performance liquid chromatography, OLIVE oil analysis, NUCLEAR magnetic resonance spectroscopy, POLYPHENOLS, OLIVE oil
Abstract

The cultivar Bianchera is an autochthonous variety from the eastern part of northern Italy, but it is also cultivated in the Slovenian and Croatian peninsula of Istria where it is named Belica (Slovenia) and Bjelica (Croatia). The properties of oleocanthal, a natural anti-inflammatory ibuprofen-like compound found in commercial monocultivar extra virgin olive oils, were determined by means of both quantitative 1H NMR (qNMR) and HPLC analyses, where qNMR was identified as a rapid and reliable method for determining the oleocanthal content. The total phenolic content (TPC) was determined by means of the Folin–Ciocalteau method and the major phenols present in the olive oils were also quantified by means of HPLC analyses. All these analyses confirmed that the cultivar Bianchera was very rich in polyphenols and satisfied the health claim provided by the EU Commission Regulation on the polyphenols content of olive oils and their beneficial effects on human health. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

7. Oleocanthal Quantification Using 1HNMR Spectroscopy and Polyphenols HPLC Analysis of Olive Oil from the Bianchera/Belica Cultivar

Author

Federico Berti, Cristina Forzato, Martina Starec, Antonella Calabretti, Starec, Martina, Calabretti, Antonella, Berti, Federico, and Forzato, Cristina

Subjects
1h nmr spectroscopy, Magnetic Resonance Spectroscopy, olive oil, polyphenols, Folin-Ciocalteau, oleocanthal, qNMR, HPLC, Pharmaceutical Science, 01 natural sciences, Article, Cyclopentane Monoterpenes, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, Phenols, lcsh:Organic chemistry, Olea, Drug Discovery, Oleocanthal, Humans, Food science, Cultivar, Physical and Theoretical Chemistry, Chromatography, High Pressure Liquid, Aldehydes, Hplc analysis, Plant Extracts, 010405 organic chemistry, 010401 analytical chemistry, Organic Chemistry, 0104 chemical sciences, Northern italy, Plant Leaves, polyphenol, chemistry, Chemistry (miscellaneous), Polyphenol, Molecular Medicine, Olive oil
Abstract

The cultivar Bianchera is an autochthonous variety from the eastern part of northern Italy, but it is also cultivated in the Slovenian and Croatian peninsula of Istria where it is named Belica (Slovenia) and Bjelica (Croatia). The properties of oleocanthal, a natural anti-inflammatory ibuprofen-like compound found in commercial monocultivar extra virgin olive oils, were determined by means of both quantitative 1HNMR (qNMR) and HPLC analyses, where qNMR was identified as a rapid and reliable method for determining the oleocanthal content. The total phenolic content (TPC) was determined by means of the Folin&ndash, Ciocalteau method and the major phenols present in the olive oils were also quantified by means of HPLC analyses. All these analyses confirmed that the cultivar Bianchera was very rich in polyphenols and satisfied the health claim provided by the EU Commission Regulation on the polyphenols content of olive oils and their beneficial effects on human health.

Published
2021
Full Text
View/download PDF

8. One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

Author

Iole Cerminara, Jessica Bais, Giorgia Regini, Federico Berti, Sara Drioli, Fabio Benedetti, Maria Funicello, Mattia Vidali, Fulvia Felluga, Bais, Jessica, Benedetti, Fabio, Berti, Federico, Cerminara, Iole, Drioli, Sara, Funicello, Maria, Regini, Giorgia, Vidali, Mattia, and Felluga, Fulvia

Subjects
Models, Molecular, Hydrochloride, BACE-1 inhibitors, Biginelli reaction, One-pot synthesis, Molecular Conformation, Pharmaceutical Science, Chemistry Techniques, Synthetic, Pyrimidinones, 010402 general chemistry, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, Alzheimer’s disease, dihydropyrimidinones, β-secretase, chemistry.chemical_compound, Structure-Activity Relationship, lcsh:Organic chemistry, Drug Discovery, Aspartic Acid Endopeptidases, Physical and Theoretical Chemistry, Guanidine, IC50, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Combinatorial chemistry, In vitro, 0104 chemical sciences, Thiourea, chemistry, Chemistry (miscellaneous), Urea, Molecular Medicine, Amyloid Precursor Protein Secretases, dihydropyrimidinone
Abstract

A library of dihydropyrimidinones was synthesized via a &ldquo, one-pot&rdquo, three component Biginelli reaction using different aldehydes in combination with &beta, dicarbonyl compounds and urea. Selected 2-thiooxo and 2-imino analogs were also obtained with the Biginelli reaction from thiourea and guanidine hydrochloride, respectively. The products were screened in vitro for their &beta, secretase inhibitory activity. The majority of the compounds resulted to be active, with IC50 in the range 100 nM&ndash, 50 &mu, M.

Published
2020
Full Text
View/download PDF

9. Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters

Author

Lidia Fanfoni, Michele Garbo, Fabio Benedetti, Fulvia Felluga, Giorgia Regini, Federico Berti, Benedetti, Fabio, Berti, Federico, Fanfoni, Lidia, Garbo, Michele, Regini, Giorgia, and Felluga, Fulvia

Subjects
Methyl Ethers, Allylic rearrangement, Sulfone, Acylation, Pharmaceutical Science, chiral pool, allylamines, amino acids, sulfones, acylation, 010402 general chemistry, 01 natural sciences, Reductive elimination, Article, Analytical Chemistry, Allylamine, lcsh:QD241-441, lcsh:Organic chemistry, Drug Discovery, Organic chemistry, Sulfones, Physical and Theoretical Chemistry, chemistry.chemical_classification, Aldehydes, Julia olefination, Amino esters, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Chiral pool, Cycloparaffins, Stereoisomerism, 0104 chemical sciences, Amino acid, Enantiopure drug, Chemistry (miscellaneous), Molecular Medicine, Allylamines, Amino acids
Abstract

The four-step conversion of a series of N-Boc-protected l-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elimination of related α-acetoxysulfones. The overall transformation takes place under mild conditions, with good yields, and without loss of stereochemical integrity, being in this respect superior to the conventional Julia reaction of α-amino aldehydes.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results