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2. A Peptide Nucleic Acid (PNA) Masking the miR-145-5p Binding Site of the 3′UTR of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) mRNA Enhances CFTR Expression in Calu-3 Cells

Author

Sultan, Shaiq, primary, Rozzi, Andrea, additional, Gasparello, Jessica, additional, Manicardi, Alex, additional, Corradini, Roberto, additional, Papi, Chiara, additional, Finotti, Alessia, additional, Lampronti, Ilaria, additional, Reali, Eva, additional, Cabrini, Giulio, additional, Gambari, Roberto, additional, and Borgatti, Monica, additional

Published
2020
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4. A Peptide Nucleic Acid against MicroRNA miR-145-5p Enhances the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Calu-3 Cells

Author

Fabbri, Enrica, primary, Tamanini, Anna, additional, Jakova, Tiziana, additional, Gasparello, Jessica, additional, Manicardi, Alex, additional, Corradini, Roberto, additional, Sabbioni, Giuseppe, additional, Finotti, Alessia, additional, Borgatti, Monica, additional, Lampronti, Ilaria, additional, Munari, Silvia, additional, Dechecchi, Maria, additional, Cabrini, Giulio, additional, and Gambari, Roberto, additional

Published
2017
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6. A Peptide Nucleic Acid against MicroRNA miR-145-5p Enhances the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Calu-3 Cells.

Author

Fabbri, Enrica, Tamanini, Anna, Jakova, Tiziana, Gasparello, Jessica, Manicardi, Alex, Corradini, Roberto, Sabbioni, Giuseppe, Finotti, Alessia, Borgatti, Monica, Lampronti, Ilaria, Munari, Silvia, Dechecchi, Maria Cristina, Cabrini, Giulio, and Gambari, Roberto

Subjects
PEPTIDE nucleic acids, MICRORNA, GENE expression, CYSTIC fibrosis transmembrane conductance regulator, AIR pollutants
Abstract

Peptide nucleic acids (PNAs) are very useful tools for gene regulation at different levels, but in particular in the last years their use for targeting microRNA (anti-miR PNAs) has provided impressive advancements. In this respect, microRNAs related to the repression of cystic fibrosis transmembrane conductance regulator (CFTR) gene, which is defective in cystic fibrosis, are of great importance in the development of new type of treatments. In this paper we propose the use of an anti-miR PNA for targeting miR-145, a microRNA reported to suppress CFTR expression. Octaarginine-anti-miR PNA conjugates were delivered to Calu-3 cells, exerting sequence dependent targeting of miR-145-5p. This allowed to enhance expression of the miR-145 regulated CFTR gene, analyzed at mRNA (RT-qPCR, Reverse Transcription quantitative Polymerase Chain Reaction) and CFTR protein (Western blotting) level. [ABSTRACT FROM AUTHOR]

Published
2018
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