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5. Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives

Author

Li-Ming Hu, Jian-Jun Tan, Cheng-Chu Zeng, Hong-Qiu He, Zi-Guo Jiao, and Cun-Xin Wang

Subjects
styrylquinoline derivatives, HIV-1 IN inhibitors, N-(styryl-8-hydroxyquinolin-7-yl)-benzenesulfonamide derivatives, Organic chemistry, QD241-441
Abstract

Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated.

Published
2010
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6. Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

Author

Li-Ming Hu, Ru-gang Zhong, Zi-Guo Jiao, Cheng-Chu Zeng, and Yi-Sheng Xu

Subjects
4-Oxo-4H-quinolizine-3-carboxylic acid derivatives, HIV-1 integrase, Mg2+ binding, Aryl diketo acids, Organic chemistry, QD241-441
Abstract

4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by 1H-NMR, 13C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.

Published
2009
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10. Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives

Author

Zi-Guo Jiao, Cunxin Wang, Jianjun Tan, Liming Hu, Cheng-Chu Zeng, and Hongqiu He

Subjects
Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Stereochemistry, Drug Evaluation, Preclinical, Human immunodeficiency virus (HIV), N-(styryl-8-hydroxyquinolin-7-yl)-benzenesulfonamide derivatives, Pharmaceutical Science, Integrase inhibitor, medicine.disease_cause, Article, Analytical Chemistry, lcsh:QD241-441, lcsh:Organic chemistry, Drug Discovery, medicine, HIV Integrase Inhibitors, HIV-1 IN inhibitors, Physical and Theoretical Chemistry, styrylquinoline derivatives, Sulfonamides, biology, Chemistry, Anti hiv, Organic Chemistry, Nuclear magnetic resonance spectroscopy, Integrase, Design synthesis, Chemistry (miscellaneous), biology.protein, Molecular Medicine
Abstract

Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized, and their possible HIV IN inhibitory activity was evaluated.

Published
2010

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