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22 results on '"Khan, Haroon"'

3. Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight

Author

Shah, Muhammad Ajmal, primary, Hamid, Ayesha, additional, Faheem, Hafiza Ishmal, additional, Rasul, Azhar, additional, Baokbah, Tourki A. S., additional, Haris, Muhammad, additional, Yousaf, Rimsha, additional, Saleem, Uzma, additional, Iqbal, Shabnoor, additional, Alves, Maria Silvana, additional, Khan, Zahid, additional, Hussain, Ghulam, additional, Alsharfi, Ifat, additional, Khan, Haroon, additional, and Jeandet, Philippe, additional

Published
2022
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5. Multifaced Assessment of Antioxidant Power, Phytochemical Metabolomics, In-Vitro Biological Potential and In-Silico Studies of Neurada procumbens L.: An Important Medicinal Plant

Author

Khurshid, Umair, primary, Ahmad, Saeed, additional, Saleem, Hammad, additional, LodhI, Arslan Hussain, additional, Pervaiz, Irfan, additional, Khan, Mohsin Abbas, additional, Khan, Haroon, additional, AlamrI, Abdulwahab, additional, AnsarI, Mukhtar, additional, LocatellI, Marcello, additional, Arshad, Muhammad Adeel, additional, Wazir, Muhammad Asif, additional, Butt, Juwairiya, additional, and Anwar, Sirajudheen, additional

Published
2022
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7. Phytochemical Profiling, Anti-Inflammatory, Anti-Oxidant and In-Silico Approach of Cornus macrophylla Bioss (Bark)

Author

Khan, Ali, primary, Pervaiz, Aini, additional, Ansari, Bushra, additional, Ullah, Riaz, additional, Shah, Syed Muhammad Mukarram, additional, Khan, Haroon, additional, Saeed Jan, Muhammad, additional, Hussain, Fida, additional, Ijaz Khan, Mohammad, additional, Albadrani, Ghadeer M., additional, Altyar, Ahmed E., additional, and Abdel-Daim, Mohamed M., additional

Published
2022
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14. Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies

Author

Mirzaei, Sepideh, primary, Hushmandi, Kiavash, additional, Zabolian, Amirhossein, additional, Saleki, Hossein, additional, Torabi, Seyed Mohammad Reza, additional, Ranjbar, Adnan, additional, SeyedSaleh, SeyedHesam, additional, Sharifzadeh, Seyed Omid, additional, Khan, Haroon, additional, Ashrafizadeh, Milad, additional, Zarrabi, Ali, additional, and Ahn, Kwang-seok, additional

Published
2021
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20. Kaempferol: A Key Emphasis to Its Anticancer Potential

Author

Imran, Muhammad, primary, Salehi, Bahare, additional, Sharifi-Rad, Javad, additional, Aslam Gondal, Tanweer, additional, Saeed, Farhan, additional, Imran, Ali, additional, Shahbaz, Muhammad, additional, Tsouh Fokou, Patrick Valere, additional, Umair Arshad, Muhammad, additional, Khan, Haroon, additional, Guerreiro, Susana G., additional, Martins, Natália, additional, and Estevinho, Leticia M., additional

Published
2019
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22. Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects.

Author

Shahcheraghi, Seyed Hossein, Salemi, Fateme, Peirovi, Niloufar, Ayatollahi, Jamshid, Alam, Waqas, Khan, Haroon, and Saso, Luciano

Subjects
NUCLEAR factor E2 related factor, KEAP1 (Protein), CURCUMIN, INSULIN resistance, ANTINEOPLASTIC agents
Abstract

Nuclear factor erythroid 2 p45-related factor (2Nrf2) is an essential leucine zipper protein (bZIP) that is primarily located in the cytoplasm under physiological conditions. Nrf2 principally modulates endogenous defense in response to oxidative stress in the brain.In this regard, Nrf2 translocates into the nucleus and heterodimerizes with the tiny Maf or Jun proteins. It then attaches to certain DNA locations in the nucleus, such as electrophile response elements (EpRE) or antioxidant response elements (ARE), to start the transcription of cytoprotective genes. Many neoplasms have been shown to have over activated Nrf2, strongly suggesting that it is responsible for tumors with a poor prognosis. Exactly like curcumin, Zinc–curcumin Zn (II)–curc compound has been shown to induce Nrf2 activation. In the cancer cell lines analyzed, Zinc–curcumin Zn (II)–curc compound can also display anticancer effects via diverse molecular mechanisms, including markedly increasing heme oxygenase-1 (HO-1) p62/SQSTM1 and the Nrf2 protein levels along with its targets. It also strikingly decreases the levels of Nrf2 inhibitor, Kelch-like ECH-associated protein 1 (Keap1) protein.As a result, the crosstalk between p62/SQSTM1 and Nrf2 could be used to improve cancer patient response to treatments. The interconnected anti-inflammatory and antioxidative properties of curcumin resulted from its modulatory effects on Nrf2 signaling pathway have been shown to improve insulin resistance. Curcumin exerts its anti-inflammatory impact through suppressing metabolic reactions and proteins such as Keap1 that provoke inflammation and oxidation. A rational amount of curcumin-activated antioxidant Nrf2 HO-1 and Nrf2-Keap1 pathways and upregulated the modifier subunit of glutamate-cysteine ligase involved in the production of the intracellular antioxidant glutathione. Enhanced expression of glutamate-cysteine ligase, a modifier subunit (GLCM), inhibited transcription of glutamate-cysteine ligase, a catalytic subunit (GCLC). A variety of in vivo, in vitro and clinical studies has been done so far to confirm the protective role of curcumin via Nrf2 regulation. This manuscript is designed to provide a comprehensive review on the molecular aspects of curcumin and its derivatives/analogs via regulation of Nrf2 regulation. [ABSTRACT FROM AUTHOR]

Published
2022
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