1. Eugenol-Functionalized Magnetite Nanoparticles Modulate Virulence and Persistence in Pseudomonas aeruginosa Clinical Strains
- Author
-
Alexandru Mihai Grumezescu, Ovidiu-Cristian Oprea, Sajjad Mohsin I Rayyif, Carmen Curutiu, Lia-Mara Ditu, Alexandra Cătălina Bîrcă, Irina Gheorghe, Alina-Maria Holban, Mariana Carmen Chifiriuc, Grigore Mihaescu, and Hamzah Basil Mohammed
- Subjects
medicine.drug_class ,Virulence Factors ,Antibiotics ,Pharmaceutical Science ,Virulence ,Microbial Sensitivity Tests ,medicine.disease_cause ,Article ,biofilm ,Analytical Chemistry ,Microbiology ,lcsh:QD241-441 ,03 medical and health sciences ,chemistry.chemical_compound ,lcsh:Organic chemistry ,Ciprofloxacin ,Drug Discovery ,Eugenol ,medicine ,Humans ,Pseudomonas Infections ,Physical and Theoretical Chemistry ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,virulence modulation ,030306 microbiology ,Pseudomonas aeruginosa ,Organic Chemistry ,Biofilm ,Quorum Sensing ,persistent infections ,Phenotype ,Anti-Bacterial Agents ,magnetite nanoparticles ,Enzyme ,chemistry ,Chemistry (miscellaneous) ,Biofilms ,Molecular Medicine ,medicine.drug - Abstract
Efficient antibiotics to cure Pseudomonas aeruginosa persistent infections are currently insufficient and alternative options are needed. A promising lead is to design therapeutics able to modulate key phenotypes in microbial virulence and thus control the progression of the infectious process without selecting resistant mutants. In this study, we developed a nanostructured system based on Fe3O4 nanoparticles (NPs) and eugenol, a natural plant-compound which has been previously shown to interfere with microbial virulence when utilized in subinhibitory concentrations. The obtained functional NPs are crystalline, with a spherical shape and 10–15 nm in size. The subinhibitory concentrations (MIC 1/2) of the eugenol embedded magnetite NPs (Fe3O4@EUG) modulate key virulence phenotypes, such as attachment, biofilm formation, persister selection by ciprofloxacin, and the production of soluble enzymes. To our knowledge, this is the first report on the ability of functional magnetite NPs to modulate P. aeruginosa virulence and phenotypic resistance, our data highlights the potential of these bioactive nanostructures to be used as anti-pathogenic agents.
- Published
- 2021
- Full Text
- View/download PDF