Search

Your search keyword '"Wang, Zhen-Hua"' showing total 10 results
Start Over Author "Wang, Zhen-Hua" Journal molecules
10 results on '"Wang, Zhen-Hua"'

3. Synthesis of Benzofuro[3,2- b ]indol-3-one Derivatives via Dearomative (3 + 2) Cycloaddition of 2-Nitrobenzofurans and para -Quinamines.

Author

Yuan, Wei-Cheng, Zeng, Hai-Ying, Zhang, Yan-Ping, Zhao, Jian-Qiang, You, Yong, Yin, Jun-Qing, Zhou, Ming-Qiang, and Wang, Zhen-Hua

Subjects
RING formation (Chemistry), DERIVATIZATION
Abstract

An efficient dearomative (3 + 2) cycloaddition of para-quinamines and 2-nitrobenzofurans has been developed. This reaction proceeds smoothly under mild conditions and affords a series of benzofuro[3,2-b]indol-3-one derivatives in good to excellent yields (up to 98%) with perfect diastereoselectivities (all cases > 20:1 dr). The scale-up synthesis and versatile derivatizations demonstrate the potential synthetic application of the protocol. A plausible reaction mechanism is also proposed to account for the observed reaction process. This work represents the first instance of the N-triggered dearomative (3 + 2) cycloaddition of 2-nitrobenzofurans. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Progress in Catalytic Asymmetric Reactions with 7-Azaindoline as the Directing Group.

Author

Zhang, Yan-Ping, You, Yong, Yin, Jun-Qing, Wang, Zhen-Hua, Zhao, Jian-Qiang, and Yuan, Wei-Cheng

Subjects
MANNICH reaction, ASYMMETRIC synthesis, CHEMISTS, AMIDES, ORGANIC synthesis, ELECTROPHILES, NUCLEOPHILES
Abstract

α-Substituted-7-azaindoline amides and α,β-unsaturated 7-azaindoline amides have emerged as new versatile synthons for various metal-catalyzed and organic-catalyzed asymmetric reactions, which have attracted much attention from chemists. In this review, the progress of research on 7-azaindoline amides in the asymmetric aldol reaction, the Mannich reaction, the conjugate addition, the 1,3-dipole cycloaddition, the Michael/aldol cascade reaction, aminomethylation and the Michael addition-initiated ring-closure reaction is discussed. The α-substituted-7-azaindoline amides, as nucleophiles, are classified according to the type of α-substituted group, whereas the α,β-unsaturated 7-azaindoline amides, as electrophiles, are classified according to the type of reaction. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results