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3 results on '"cellular distribution"'

1. A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research

Author

Jiyong Su

Subjects
Charcot-Leyden crystal protein, Galectin-10, history, cellular distribution, diseases marker, crystal structure, ligand binding specificity, Organic chemistry, QD241-441
Abstract

Eosinophils are present in tissues, such as the respiratory tract, spleen, lymph nodes and blood vessels. The significant presence of eosinophils in these tissues are associated with various diseases, including asthma, allergies, acute myeloid leukemia, etc. Charcot-Leyden crystal protein/galectin-10 is overexpressed in eosinophils and has also been identified in basophils and macrophages. In human body, this protein could spontaneously form Charcot-Leyden crystal in lymphocytes or in the lysates of lymphocytes. At present, the role of Charcot-Leyden crystal protein/galectin-10 in lymphocytes is not fully understood. This review summarizes research progress on Charcot-Leyden crystal protein/galectin-10, with emphasis on its history, cellular distributions, relations to diseases, structures and ligand binding specificity.

Published
2018
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2. Site-Specific Fluorescent Labeling of RNA Interior Positions

Author

Barry S. Cooperman

Subjects
Pharmaceutical Science, Review, Computational biology, RNA interior positions, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Drug Discovery, Animals, Humans, Transferase, Physical and Theoretical Chemistry, site-specific fluorescent labeling, Fluorescent Dyes, 030304 developmental biology, 0303 health sciences, Staining and Labeling, Chemistry, Organic Chemistry, RNA, In vitro, 0104 chemical sciences, Fluorescent labelling, Chemistry (miscellaneous), Cellular distribution, Nucleic acid, Molecular Medicine, Oligonucleotide Probes, Protein Processing, Post-Translational, Function (biology)
Abstract

The introduction of fluorophores into RNA for both in vitro and in cellulo studies of RNA function and cellular distribution is a subject of great current interest. Here I briefly review methods, some well-established and others newly developed, which have been successfully exploited to site-specifically fluorescently label interior positions of RNAs, as a guide to investigators seeking to apply this approach to their studies. Most of these methods can be applied directly to intact RNAs, including (1) the exploitation of natural posttranslational modifications, (2) the repurposing of enzymatic transferase reactions, and (3) the nucleic acid-assisted labeling of intact RNAs. In addition, several methods are described in which specifically labeled RNAs are prepared de novo.

Published
2021

3. A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research.

Author

Su, Jiyong

Subjects
*GALECTINS, *EOSINOPHILS, *GRANULOCYTES, *ASTHMA, *MACROPHAGES
Abstract

Eosinophils are present in tissues, such as the respiratory tract, spleen, lymph nodes and blood vessels. The significant presence of eosinophils in these tissues are associated with various diseases, including asthma, allergies, acute myeloid leukemia, etc. Charcot-Leyden crystal protein/galectin-10 is overexpressed in eosinophils and has also been identified in basophils and macrophages. In human body, this protein could spontaneously form Charcot-Leyden crystal in lymphocytes or in the lysates of lymphocytes. At present, the role of Charcot-Leyden crystal protein/galectin-10 in lymphocytes is not fully understood. This review summarizes research progress on Charcot-Leyden crystal protein/galectin-10, with emphasis on its history, cellular distributions, relations to diseases, structures and ligand binding specificity. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

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