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Geobarrettin D ( 1 ), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1 H- 15 N HSQC, 1 H- 15 N HMBC spectra), as well as HRESIMS data. Geobarrettin D ( 1 ) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D ( 1 ) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound 1 shows anti-inflammatory activity.