1. Crystal structure, antibacterial and cytotoxic activities of a new complex of bismuth(III) with sulfapyridine.
- Author
-
Marzano IM, Franco MS, Silva PP, Augusti R, Santos GC, Fernandes NG, Bucciarelli-Rodriguez M, Chartone-Souza E, and Pereira-Maia EC
- Subjects
- Cell Death drug effects, Cell Proliferation drug effects, Crystallography, X-Ray, Humans, Hydrogen Bonding, K562 Cells, Microbial Sensitivity Tests, Molecular Conformation, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Bismuth chemistry, Bismuth pharmacology, Sulfapyridine chemistry, Sulfapyridine pharmacology
- Abstract
A new complex of Bi(III) and sulfapyridine was synthesized and characterized by elemental analysis, atomic absorption spectrometry, conductivity analysis, electrospray ionization mass spectrometry (ESI-MS), infrared spectroscopy, and single crystal X-ray diffraction methods. The antimicrobial and the cytotoxic activities of the compound were investigated. Elemental and conductivity analyses are in accordance to the formulation [BiCl₃(C₁₁H₁₁N₃O₂S)₃]. The structure of the complex reveals a distorted octahedral geometry around the bismuth atom, which is bound to three sulfonamidic nitrogens from sulfapyridine, acting as a monodentate ligand, and to three chloride ions. The presence of the compound in solution was confirmed by ESI-MS studies. The complex is 3 times more potent than the ligand against Salmonella typhimurium, 4 times against Staphylococcus aureus, Shigella dysenteriae, and Shigella sonnei and 8 times more potent against Pseudomonas aeruginosa and Escherichia coli. The compound inhibits the growth of chronic myelogenous leukemia cells with an IC₅₀ value of 44 μM whereas the free ligand has no effect up to 100 μM.
- Published
- 2013
- Full Text
- View/download PDF