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Start Over Author "Coco N. Kapanda" Journal monatshefte fur chemie - chemical monthly
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1. Design and synthesis of 3-acyl-2(3H)-benzoxazolone and 3-acyl-2(3H)-benzothiazolone derivatives

Author

Faouzi Guenadil, Didier M. Lambert, Christopher R. McCurdy, Hocine Aichaoui, Jacques H. Poupaert, and Coco N. Kapanda

Subjects
Solvent, chemistry.chemical_compound, Chemistry, Sodium hydroxide, Acetone, Organic chemistry, lipids (amino acids, peptides, and proteins), General Chemistry
Abstract

A simpler and efficient “green” method using solid sodium hydroxide in a solvent mixture of acetone/water was found to catalyze N-acylation of 2(3H)-benzoxazolones and 2(3H)-benzothiazolones for facile and rapid synthesis of N-acyl derivatives in excellent yields. This method was applied to the synthesis of a series of 132 compounds employing a variety of acyl chlorides.

Published
2010
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