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The article offers information on neuroanatomical hypotheses. According to a researcher, stimulation is a basic inclination inherent in all living tissues towards the expression of its characteristic activity. It is also a derivative tendency in the early life history of the animal wherein it is subjected to perform random movements to various kinds of external stimulation and to the gratification of internal needs. This concept, which was developed by extensive experimentation with rats, posits that supplementation is still useful in understanding the notion of deprivation.

The article cites several animal experimentation. A researcher has discovered that albino rats which had been taken as pets were less timid and less apprehensive as opposed to those who had received infrequent handling. These animals were also known to survive thyroidectomy. Another researcher also identified that albino rats who had experienced gentle handling, stroking, and caressing or tactile simulation via strokes of a brush gained more body weight than did the nonstimulated ones. It is identified that the severity of stimulation largely contributes to this fact.