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Background . A number of weighting factors, primarily obesity and manifestations of duodenogastroesophageal reflux (DGER), are correlated with the presence of inflammation and an increased risk of progression of negative changes in the esophagus with gastroesophageal reflux disease (GERD). This should be considered when screening for GERD using esophagogastroduodenoscopy (EGDS). Objective: to draw the attention of doctors to the need for early screening of morphological changes in the mucous membrane of the esophagus among young people with obesity, as an example of a clinical case. Methods. 23-year-old man with overweight, heartburn, bloating. Heartburn has been troubling for more than two years. Smokes. Has a family history of cancer of the upper gastrointestinal tract. On endoscopy: 38 cm from the upper incisors, a single, 3 mm in diameter, polypoid whitish formation was found, it rises on a broad basis. In the stomach – a significant amount of bile. Pylorus – open. Biopsy samples of the gastric mucosa (antrum, body) were taken. A quick urease test is negative. The removal of the formation of the esophagus. In a histological examination of the formation of the esophagus, we revealed squamous papilloma with low-grade epithelial dysplasia, chronic esophagitis, and reflux gastritis. Final diagnosis: GERD with chronic esophagitis. Squamous cell papilloma of the esophagus with mild epithelial dysplasia. Reflux gastritis, inactive. Obesity of 1 degree. Results. According to the literature, obesity, smoking, a family history of cancer are risk factors for GERD and the most common events among patients with squamous esophageal papilloma. DHER promotes the formation of GERD, esophagitis, metaplasia and neoplasia of the surface epithelium of the mucous membrane of the esophagus. But there is no scientific evidence for the benefits of endoscopic screening for GERD among obese young adults. Conclusion. A clinical case demonstrates that screening endoscopy in a young man against the background of factors aggravating the course of GERD revealed lesions of the esophagus in the form of squamous papilloma with epithelial dysplasia. Further studies are needed to confirm the benefits of endoscopic screening for GERD in obese young adults.