1. Metabolic correlates of dopaminergic loss in dementia with lewy bodies
- Author
-
Alessandro Padovani, Andrea Pilotto, Nicolas Nicastro, Adrian Danek, Sonja Schönecker, Rose Bruffaerts, Afina W. Lemstra, Johannes Levin, Maja Trošt, Sara Garcia-Ptacek, Matteo Pardini, Irina Savitcheva, Jonathan Vöglein, Paul Cumming, Catharina Prix, Matteo Bauckneht, Valle Camacho, Dag Aarsland, Valentina Garibotto, Maria Huber, Boris-Stephan Rauchmann, Silvia Morbelli, Anette Davidsson, Axel Rominger, Flavio Nobili, Michael Ewers, Koen Van Laere, Leonie Beyer, Robert Perneczky, Miguel A. Ochoa-Figueroa, Enrico Peira, Cihan Catak, Dario Arnaldi, Oliver Pogarell, Milica G. Kramberger, Jonas Schnabel, Giovanni B. Frisoni, Jessica J. van der Zande, Rik Vandenberghe, Katharina Buerger, Matthias Brendel, Peter Bartenstein, Gianmario Sambuceti, Carla Palleis, Marko Grmek, Andrea Chincarini, Marcus Unterrainer, Neurology, and Amsterdam Neuroscience - Neurodegeneration
- Subjects
Lewy Body Disease ,0301 basic medicine ,Neurologi ,Dopamine ,Lewy body dementia ,PET imaging ,dopamine deficiency ,glucose metabolism ,metabolic connectivity ,610 Medicine & health ,ddc:616.0757 ,Imaging ,Cohort Studies ,ddc:616.89 ,03 medical and health sciences ,0302 clinical medicine ,Basal ganglia ,Humans ,Medicine ,Dementia ,ddc:610 ,Dopamine transporter ,Lewy body ,biology ,diagnostic imaging [Lewy Body Disease] ,business.industry ,Dementia with Lewy bodies ,Action, intention, and motor control ,Dopaminergic ,Brain ,medicine.disease ,ddc:616.8 ,3. Good health ,PET ,030104 developmental biology ,Neurology ,Hypermetabolism ,biology.protein ,Lewy Bodies ,Neurology (clinical) ,business ,Neuroscience ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background Striatal dopamine deficiency and metabolic changes are well-known phenomena in dementia with Lewy bodies and can be quantified in vivo by I-123-Ioflupane brain single-photon emission computed tomography of dopamine transporter and F-18-fluorodesoxyglucose PET. However, the linkage between both biomarkers is ill-understood. Objective We used the hitherto largest study cohort of combined imaging from the European consortium to elucidate the role of both biomarkers in the pathophysiological course of dementia with Lewy bodies. Methods We compared striatal dopamine deficiency and glucose metabolism of 84 dementia with Lewy body patients and comparable healthy controls. After normalization of data, we tested their correlation by region-of-interest-based and voxel-based methods, controlled for study center, age, sex, education, and current cognitive impairment. Metabolic connectivity was analyzed by inter-region coefficients stratified by dopamine deficiency and compared to healthy controls. Results There was an inverse relationship between striatal dopamine availability and relative glucose hypermetabolism, pronounced in the basal ganglia and in limbic regions. With increasing dopamine deficiency, metabolic connectivity showed strong deteriorations in distinct brain regions implicated in disease symptoms, with greatest disruptions in the basal ganglia and limbic system, coincident with the pattern of relative hypermetabolism. Conclusions Relative glucose hypermetabolism and disturbed metabolic connectivity of limbic and basal ganglia circuits are metabolic correlates of dopamine deficiency in dementia with Lewy bodies. Identification of specific metabolic network alterations in patients with early dopamine deficiency may serve as an additional supporting biomarker for timely diagnosis of dementia with Lewy bodies. (c) 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. Funding Agencies|Velox Foundation [project 1123]; Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung [SNF 320030_169876]
- Published
- 2020
- Full Text
- View/download PDF