1. Level I PD‐MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia
- Author
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Boel, Judith A, de Bie, Rob MA, Schmand, Ben A, Dalrymple‐Alford, John C, Marras, Connie, Adler, Charles H, Goldman, Jennifer G, Tröster, Alexander I, Burn, David J, Litvan, Irene, Geurtsen, Gert J, Bernard, Bryan, Stebbins, Glenn, Filoteo, J Vincent, Weintraub, Daniel, Caviness, John N, Belden, Christine, Zabetian, Cyrus P, Cholerton, Brenna A, Huang, Xuemei, Eslinger, Paul J, Leverenz, James B, Duff‐Canning, Sarah, Farrer, Matt, Anderson, Tim J, Myall, Daniel J, Naismith, Sharon L, Lewis, Simon JG, Halliday, Glenda M, Wu, Ruey‐Meei, Williams‐Gray, Caroline H, Breen, David P, Barker, Roger A, Yarnall, Alison J, Klein, Martin, Mollenhauer, Brit, Trenkwalder, Claudia, Kulisevsky, Jaime, Pagonabarraga, Javier, Gasca‐Salas, Carmen, Rodriguez‐Oroz, Maria C, Junque, Carme, Segura, Barbara, Barone, Paolo, Santangelo, Gabriella, Cammisuli, Davide M, Biundo, Roberta, Antonini, Angelo, Weis, Luca, Pedersen, Kenn Freddy, and Alves, Guido
- Subjects
Acquired Cognitive Impairment ,Neurodegenerative ,Neurosciences ,Parkinson's Disease ,Dementia ,Clinical Research ,Aging ,Brain Disorders ,Neurological ,dementia ,mild cognitive impairment ,global cognitive tests ,Parkinson's disease ,diagnostic accuracy ,MDS Study Group Mild Cognitive Impairment in Parkinson's Disease - Abstract
BackgroundThe criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.MethodsThe MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to define PD-MCI (n = 467). Risk for developing PDD was examined using a Cox model. Global cognitive tests were compared to neuropsychological test batteries (Level I&II) in determining risk for PDD.ResultsPD-MCI based on a global cognitive test (MMSE or MoCA) increases the hazard for developing PDD (respectively HR = 2.57, P = 0.001; HR = 4.14, P =
- Published
- 2022