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1. SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study

Author

Sormani, Maria Pia, primary, Schiavetti, Irene, additional, Landi, Doriana, additional, Carmisciano, Luca, additional, De Rossi, Nicola, additional, Cordioli, Cinzia, additional, Moiola, Lucia, additional, Radaelli, Marta, additional, Immovilli, Paolo, additional, Capobianco, Marco, additional, Brescia Morra, Vincenzo, additional, Trojano, Maria, additional, Tedeschi, Gioacchino, additional, Comi, Giancarlo, additional, Battaglia, Mario Alberto, additional, Patti, Francesco, additional, Fragoso, Yara Dadalti, additional, Sen, Sedat, additional, Siva, Aksel, additional, Furlan, Roberto, additional, Salvetti, Marco, additional, Abbadessa, Gianmarco, additional, Aguglia, Umberto, additional, Allegorico, Lia, additional, Allegri, Rossi Beatrice Maria, additional, Amato, Maria Pia, additional, Annovazzi, Pietro, additional, Antozzi, Carlo, additional, Appendino, Lucia, additional, Arena, Sebastiano, additional, Baione, Viola, additional, Balgera, Roberto, additional, Barcella, Valeria, additional, Baroncini, Damiano, additional, Barrilà, Caterina, additional, Battaglia, Mario A., additional, Bellacosa, Alessandra, additional, Bellucci, Gianmarco, additional, Bergamaschi, Roberto, additional, Bergamaschi, Valeria, additional, Bezzini, Daiana, additional, Biolzi, Beatrice, additional, Bisecco, Alvino, additional, Bonavita, Simona, additional, Borriello, Giovanna, additional, Bosa, Chiara, additional, Bosco, Antonio, additional, Bovis, Francesca, additional, Bozzali, Marco, additional, Brambilla, Laura, additional, Brescia, Morra Vincenzo, additional, Brichetto, Giampaolo, additional, Buccafusca, Maria, additional, Bucciantini, Elisabetta, additional, Bucello, Sebastiano, additional, Buscarinu, Maria Chiara, additional, Cabboi, Maria Paola, additional, Calabrese, Massimiliano, additional, Calabria, Francesca, additional, Caleri, Francesca, additional, Camilli, Federico, additional, Caniatti, Luisa Maria, additional, Cantello, Roberto, additional, Capra, Ruggero, additional, Capuano, Rocco, additional, Carta, Patrizia, additional, Cavalla, Paola, additional, Celani, Maria Grazia, additional, Cellerino, Maria, additional, Cerqua, Raffaella, additional, Chisari, Clara, additional, Clerici, Raffaella, additional, Clerico, Marinella, additional, Cocco, Eleonora, additional, Cola, Gaia, additional, Confalonieri, Paolo, additional, Conte, Antonella, additional, Conti, Marta Zaffira, additional, Cordano, Christian, additional, Cordera, Susanna, additional, Corea, Francesco, additional, Correale, Claudio, additional, Cottone, Salvatore, additional, Crescenzo, Francesco, additional, Curti, Erica, additional, d’Ambrosio, Alessandro, additional, D’Amico, Emanuele, additional, Danni, Maura Chiara, additional, d’Arma, Alessia, additional, Dattola, Vincenzo, additional, de Biase, Stefano, additional, De Luca, Giovanna, additional, De Mercanti, Stefania Federica, additional, De Mitri, Paolo, additional, De Stefano, Nicola, additional, Della Cava, Marco, additional, di Napoli, Mario, additional, Di Sapio, Alessia, additional, Docimo, Renato, additional, Dutto, Anna, additional, Evangelista, Luana, additional, Fanara, Salvatore, additional, Ferraro, Diana, additional, Ferrò, Maria Teresa, additional, Filippi, Massimo, additional, Fioretti, Cristina, additional, Fratta, Mario, additional, Frau, Jessica, additional, Fronza, Marzia, additional, Gajofatto, Alberto, additional, Gallo, Antonio, additional, Gallo, Paolo, additional, Gasperini, Claudio, additional, Ghazaryan, Anna, additional, Giometto, Bruno, additional, Gobbin, Francesca, additional, Govone, Flora, additional, Granella, Franco, additional, Grange, Erica, additional, Grasso, Maria Grazia, additional, Guareschi, Angelica, additional, Guaschino, Clara, additional, Guerrieri, Simone, additional, Guidetti, Donata, additional, Iaffaldano, Pietro, additional, Ianniello, Antonio, additional, Iasevoli, Luigi, additional, Imperiale, Daniele, additional, Infante, Maria Teresa, additional, Inglese, Matilde, additional, Iodice, Rosa, additional, Iovino, Aniello, additional, Konrad, Giovanna, additional, Lanzillo, Roberta, additional, Lapucci, Caterina, additional, Lavorgna, Luigi, additional, L’Episcopo Maria, Rita, additional, Leva, Serena, additional, Liberatore, Giuseppe, additional, Lo Re, Marianna, additional, Longoni, Marco, additional, Lopiano, Leonardo, additional, Lorefice, Lorena, additional, Lucchini, Matteo, additional, Lus, Giacomo, additional, Maimone, Davide, additional, Malentacchi, Maria, additional, Mallucci, Giulia, additional, Malucchi, Simona, additional, Mancinelli, Chiara Rosa, additional, Mancinelli, Luca, additional, Manganotti, Paolo, additional, Maniscalco, Teresa Giorgia, additional, Mantero, Vittorio, additional, Marangoni, Sabrina, additional, Marastoni, Damiano, additional, Marfia, Alessandra Girolama, additional, Marinelli, Fabiana, additional, Marti, Alessandro, additional, Martinelli Boneschi, Filippo, additional, Masserano Zoli, Federco, additional, Matta, Francesca, additional, Mendozzi, Laura, additional, Meucci, Giuseppe, additional, Miante, Silvia, additional, Miele, Giuseppina, additional, Milano, Eva, additional, Mirabella, Massimiliano, additional, Missione, Rosanna, additional, Moccia, Marcello, additional, Montepietra, Sara, additional, Monti Bragadin, Margherita, additional, Montini, Federico, additional, Motta, Roberta, additional, Nardone, Raffaele, additional, Nicoletti, Carolina Gabri, additional, Nobile-Orazio, Eduardo, additional, Nozzolillo, Agostino, additional, Onofrj, Marco, additional, Orlandi, Riccardo, additional, Palmieri, Anna, additional, Paolicelli, Damiano, additional, Pasquali, Livia, additional, Pastò, Luisa, additional, Pedrazzoli, Elisabetta, additional, Perini, Paola, additional, Pesci, Ilaria, additional, Petracca, Maria, additional, Petrone, Alfredo, additional, Piantadosi, Carlo, additional, Pietroboni, Anna M., additional, Pinardi, Federica, additional, Ponzano, Marta, additional, Portaccio, Emilio, additional, Pozzato, Mattia, additional, Pozzilli, Carlo, additional, Prosperini, Luca, additional, Protti, Alessandra, additional, Ragonese, Paolo, additional, Rasia, Sarah, additional, Realmuto, Sabrina, additional, Repice, Anna, additional, Rigoni, Eleonora, additional, Rilla, Maria Teresa, additional, Rinaldi, Francesca, additional, Romano, Calogero Marcello, additional, Ronzoni, Marco, additional, Rovaris, Marco, additional, Ruscica, Francesca, additional, Sabattini, Loredana, additional, Salemi, Giuseppe, additional, Saraceno, Lorenzo, additional, Sartori, Alessia, additional, Sartori, Arianna, additional, Sbragia, Elvira, additional, Scandellari, Cinzia, additional, Scarano Giuditta, Ilaria, additional, Scarano, Valentina, additional, Schillaci, Valentina, additional, Sessa, Maria, additional, Sgarito, Caterina, additional, Sibilia, Grazia, additional, Siciliano, Gabriele, additional, Signori, Alessio, additional, Signoriello, Elisabetta, additional, Sinisi, Leonardo, additional, Sireci, Francesca, additional, Sola, Patrizia, additional, Solaro, Claudio, additional, Sormani, Maria Pia, additional, Sotgiu, Stefano, additional, Sparaco, Maddalena, additional, Stromillo, Maria Laura, additional, Strumia, Silvia, additional, Susani, Laura Emanuela, additional, Tabiadon, Giulietta, additional, Teatini, Francesco, additional, Tomassini, Valentina, additional, Tonietti, Simone, additional, Torri, Clerici Valentina, additional, Tortorella, Carla, additional, Toscano, Simona, additional, Totaro, Rocco, additional, Trotta, Maria, additional, Turano, Gabriella, additional, Ulivelli, Monica, additional, Valentino, Manzo, additional, Vaula, Giovanna, additional, Vecchio, Domizia, additional, Vercellino, Marco, additional, Verrengia, Elena Pinuccia, additional, Vianello, Marika, additional, Virgilio, Eleonora, additional, Vitetta, Francesca, additional, Vollaro, Stefano, additional, Zaffaroni, Mauro, additional, Zampolini, Mauro, additional, Zarbo, Ignazio Roberto, additional, Zito, Antonio, additional, and Zuliani, Luigi, additional

Published
2021
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2. Alemtuzumab in multiple sclerosis during the COVID-19 pandemic: A mild uncomplicated infection despite intense immunosuppression

Author

Carandini, Tiziana, primary, Pietroboni, Anna Margherita, additional, Sacchi, Luca, additional, De Riz, Milena Alessandra, additional, Pozzato, Mattia, additional, Arighi, Andrea, additional, Fumagalli, Giorgio Giulio, additional, Martinelli Boneschi, Filippo, additional, Galimberti, Daniela, additional, and Scarpini, Elio, additional

Published
2020
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3. A pharmacogenetic study implicates NINJ2 in the response to Interferon-β in multiple sclerosis

Author

Peroni, Silvia, primary, Sorosina, Melissa, additional, Malhotra, Sunny, additional, Clarelli, Ferdinando, additional, Osiceanu, Ana Maria, additional, Ferrè, Laura, additional, Roostaei, Tina, additional, Rio, Jordi, additional, Midaglia, Luciana, additional, Villar, Luisa María, additional, Álvarez-Cermeño, José Carlos, additional, Guaschino, Clara, additional, Radaelli, Marta, additional, Citterio, Lorena, additional, Lechner-Scott, Jeannette, additional, Spataro, Nino, additional, Navarro, Arcadi, additional, Martinelli, Vittorio, additional, Montalban, Xavier, additional, Weiner, Howard L, additional, de Jager, Philip, additional, Comi, Giancarlo, additional, Esposito, Federica, additional, Comabella, Manuel, additional, and Martinelli-Boneschi, Filippo, additional

Published
2019
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4. The burden of multiple sclerosis variants in continental Italians and Sardinians

Author

Sanna, Serena, Barizzone, Nadia, Zara, Ilenia, Sorosina, Melissa, Lupoli, Sara, Porcu, Eleonora, Pitzalis, Maristella, Zoledziewska, Magdalena, Esposito, Federica, Leone, Maurizio, Mulas, Antonella, Cocco, Eleonora, Ferrigno, Paola, Guerini, Franca R., Brambilla, Paola, Farina, Gabriele, Murru, Raffaele, Deidda, Francesca, Sanna, Sonia, Loi, Alessia, Barlassina, Cristina, Vecchio, Domizia, Zauli, Andrea, Clarelli, Ferdinando, Braga, Daniele, Poddie, Fausto, Cantello, Roberto, Martinelli, Vittorio, Comi, Giancarlo, Frau, Jessica, Lorefice, Lorena, Pugliatti, Maura, Rosati, Giulio, Progemus, Salvetti, Marco, Melis, Maurizio, Marrosu, Maria G., Cusi, Daniele, Cucca, Francesco, Martinelli Boneschi, Filippo, D'Alfonso, Sandra, Faculteit Medische Wetenschappen/UMCG, and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Subjects
single nucleotide, Risk, medicine.medical_specialty, Multiple Sclerosis, Genotype, autoimmune disease, sardinia, Human leukocyte antigen, Biology, Research Support, genetic risk score, Polymorphism, Single Nucleotide, NO, polymorphism, human leukocyte antigen, HLA Antigens, Epidemiology, Journal Article, medicine, Humans, genetics, Genetic Predisposition to Disease, Genetic risk, Non-U.S. Gov't, Autoimmune disease, epidemiology, Italy, Mediterranean populations, multiple sclerosis, Sardinia, Neurology (clinical), Neurology, Genetics, italy, mediterranean populations, biomarkers, genotype, hla antigens, humans, polymorphism, single nucleotide, risk, genetic predisposition to disease, neurology, neurology (clinical), Receiver operating characteristic, Research Support, Non-U.S. Gov't, Multiple sclerosis, medicine.disease, Biomarkers
Abstract

Background: Recent studies identified > 100 non-HLA (human leukocyte antigen) multiple sclerosis (MS) susceptibility variants in Northern European populations, but their role in Southern Europeans is largely unexplored. Objective: We aimed to investigate the cumulative impact of those variants in two Mediterranean populations: Continental Italians and Sardinians. Methods: We calculated four weighted Genetic Risk Scores (wGRS), using up to 102 non-HLA MS risk variants and 5 HLA MS susceptibility markers in 1691 patients and 2194 controls from continental Italy; and 2861 patients and 3034 controls from Sardinia. We then assessed the differences between populations using Nagelkerke’s R2 and the area under the Receiver Operating Characteristic (ROC) curves. Results: As expected, the genetic burden (mean wGRS value) was significantly higher in MS patients than in controls, in both populations. Of note, the burden was significantly higher in Sardinians. Conversely, the proportion of variability explained and the predictive power were significantly higher in continental Italians. Notably, within the Sardinian patients, we also observed a significantly higher burden of non-HLA variants in individuals who do not carry HLA risk alleles. Conclusions: The observed differences in MS genetic burden between the two Mediterranean populations highlight the need for more genetic studies in South Europeans, to further expand the knowledge of MS genetics.

Published
2015

6. NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

Author

Malhotra, Sunny, primary, Sorosina, Melissa, additional, Río, Jordi, additional, Peroni, Silvia, additional, Midaglia, Luciana, additional, Villar, Luisa M, additional, Álvarez-Cermeño, José C, additional, Schroeder, Ina, additional, Esposito, Federica, additional, Clarelli, Ferdinando, additional, Zettl, Uwe K, additional, Lechner-Scott, Jeannette, additional, Spataro, Nino, additional, Navarro, Arcadi, additional, Comi, Giancarlo, additional, Montalban, Xavier, additional, Martinelli-Boneschi, Filippo, additional, and Comabella, Manuel, additional

Published
2017
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7. Functional network connectivity abnormalities in multiple sclerosis: Correlations with disability and cognitive impairment

Author

Rocca, Maria A, primary, Valsasina, Paola, additional, Leavitt, Victoria M, additional, Rodegher, Mariaemma, additional, Radaelli, Marta, additional, Riccitelli, Gianna C, additional, Martinelli, Vittorio, additional, Martinelli-Boneschi, Filippo, additional, Falini, Andrea, additional, Comi, Giancarlo, additional, and Filippi, Massimo, additional

Published
2017
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8. Functional and structural plasticity following action observation training in multiple sclerosis.

Author

Rocca, Maria A, Meani, Alessandro, Fumagalli, Silvia, Pagani, Elisabetta, Gatti, Roberto, Martinelli-Boneschi, Filippo, Esposito, Federica, Preziosa, Paolo, Cordani, Claudio, Comi, Giancarlo, and Filippi, Massimo

Subjects
MULTIPLE sclerosis, FUNCTIONAL magnetic resonance imaging, ARM, OBJECT manipulation
Abstract

Background: Hand motor deficits contribute to multiple sclerosis (MS)-related disability. Action observation training (AOT) is promising to improve upper limb function in neurologic patients. Objectives: In this preliminary study, we investigated AOT effects on dominant-hand motor performance in MS patients with upper limb motor impairment and performed an explorative analysis of their anatomical and functional magnetic resonance imaging (MRI) substrates. Methods: In total, 46 healthy controls (HC) and 41 MS patients with dominant-hand motor impairment were randomized to AOT (HC-AOT = 23; MS-AOT = 20; watching daily-life action videos and execution) or control-training (HC-Control = 23; MS-Control = 21; watching landscapes videos and execution). Behavioral, structural, and functional (at rest and during object manipulation) MRI scans were acquired before and after a 2-week training. Results: After training, MS groups improved in right upper limb functions, mainly in AOT group (p from 0.02 to 0.0001). All groups showed regional increased and decreased gray matter volume, with specific AOT effects in fronto-temporal areas in MS-AOT (p < 0.001), without white matter (WM) integrity modifications. Increased and reduced recruitments of the action observation matching system and its connections in MS-AOT were found (p < 0.001). Motor improvements were correlated with volumetric and functional MRI modifications (r from −0.78 to 0.77, p < 0.001). Conclusion: The 10-day AOT promotes clinical improvements in MS patients through structural and functional modifications of the action observation matching system. [ABSTRACT FROM AUTHOR]

Published
2019
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9. NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients.

Author

Malhotra, Sunny, Sorosina, Melissa, Río, Jordi, Peroni, Silvia, Midaglia, Luciana, Villar, Luisa M., Álvarez-Cermeño, José C., Schroeder, Ina, Esposito, Federica, Clarelli, Ferdinando, Zettl, Uwe K., Lechner-Scott, Jeannette, Spataro, Nino, Navarro, Arcadi, Comi, Giancarlo, Montalban, Xavier, Martinelli-Boneschi, Filippo, and Comabella, Manuel

Subjects
GENETIC polymorphisms, INTERFERON beta 1b, GENETICS of multiple sclerosis, MYELIN sheath diseases, GENOTYPES
Abstract

We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients. [ABSTRACT FROM AUTHOR]

Published
2018
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10. Functional network connectivity abnormalities in multiple sclerosis: Correlations with disability and cognitive impairment.

Author

Rocca, Maria A., Valsasina, Paola, Leavitt, Victoria M., Rodegher, Mariaemma, Radaelli, Marta, Riccitelli, Gianna C., Martinelli, Vittorio, Martinelli-Boneschi, Filippo, Falini, Andrea, Comi, Giancarlo, and Filippi, Massimo

Subjects
FUNCTIONAL magnetic resonance imaging, BRAIN imaging, MULTIPLE sclerosis, MILD cognitive impairment, MAGNETIC resonance imaging of the brain
Abstract

Objective: To investigate resting state (RS) functional connectivity (FC) abnormalities within the principal brain networks in a large cohort of multiple sclerosis (MS) patients, to define the trajectory of FC changes over disease stages and their relation with clinical and structural magnetic resonance imaging (MRI) measures. Methods: RS functional magnetic resonance imaging (fMRI), clinical, and neuropsychological evaluation were obtained from 215 MS patients and 98 healthy controls. Connectivity abnormalities and correlations with clinical/neuropsychological/imaging measures were evaluated. We analyzed seed-voxel FC with seven major hubs, producing one visual/sensory, one motor, two cognitive, one cerebellar, and two subcortical networks. Results: MS patients showed reduced network average RS FC versus controls in the default-mode network. At regional level, a complex pattern of decreased and increased RS FC was found. Reduced RS FC mainly involved sensorimotor, cognitive, thalamic, and cerebellar networks, whereas increased RS FC involved visual/sensory and subcortical networks. Reduced RS FC correlated with T2 lesions. Reduced thalamic RS FC correlated with better neuropsychological performance, whereas for all remaining networks reduced FC correlated with more severe clinical/cognitive impairment. Conclusion: Increased and decreased RS FC occurs in MS and contributes to a wide spectrum of clinical manifestations. RS FC reduction is related to T2 lesions. Such a paradigm is inverted for the thalamic network. [ABSTRACT FROM AUTHOR]

Published
2018
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11. A genome-wide association study in progressive multiple sclerosis

Author

Martinelli-Boneschi, Filippo, primary, Esposito, Federica, additional, Brambilla, Paola, additional, Lindström, Eva, additional, Lavorgna, Giovanni, additional, Stankovich, Jim, additional, Rodegher, Mariaemma, additional, Capra, Ruggero, additional, Ghezzi, Angelo, additional, Coniglio, Gabriella, additional, Colombo, Bruno, additional, Sorosina, Melissa, additional, Martinelli, Vittorio, additional, Booth, David, additional, Oturai, Annette Bang, additional, Stewart, Graeme, additional, Harbo, Hanne F., additional, Kilpatrick, Trevor John, additional, Hillert, Jan, additional, Rubio, Justin P, additional, Abderrahim, Hadi, additional, Wojcik, Jerome, additional, and Comi, Giancarlo, additional

Published
2012
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13. Inverse correlation of genetic risk score with age at onset in bout-onset and progressive-onset multiple sclerosis.

Author

Sorosina, Melissa, Esposito, Federica, Guaschino, Clara, Clarelli, Ferdinando, Barizzone, Nadia, Osiceanu, Ana Maria, Brambilla, Paola, Mascia, Elisabetta, Cavalla, Paola, Gallo, Paolo, Martinelli, Vittorio, Leone, Maurizio, Comi, Giancarlo, D’Alfonso, Sandra, and Martinelli Boneschi, Filippo

Subjects
MULTIPLE sclerosis risk factors, DISEASE susceptibility, AGE of onset, HETEROGENEITY, DISEASE progression, SINGLE nucleotide polymorphisms
Abstract

We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n=906) and progressive-onset MS Italian patients (PrMS) (n=544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= −0.1; p=5 × 10−3) and a later age at onset in PrMS cases (rho=0.07; p=0.15) (p of difference of regression=1.4 × 10−2). These findings suggest that established MS risk variants anticipate the onset of the inflammatory phase, while they have no impact on, or even delay, the onset of the progressive phase. [ABSTRACT FROM AUTHOR]

Published
2015
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