Search

Your search keyword '"Otero, Susana"' showing total 3 results
Start Over Author "Otero, Susana" Journal multiple sclerosis journal
3 results on '"Otero, Susana"'

2. Menopause and multiple sclerosis: Influence on prognosis and role of disease-modifying drugs and hormonal replacement therapy.

Author

Midaglia, Luciana, Otero, Susana, Baró, Francesc, Montalban, Xavier, and Tintoré, Mar

Subjects
*HOT flashes, *MULTIPLE sclerosis, *HORMONE therapy, *MENOPAUSE, *PROGNOSIS, *AGE of onset
Abstract

Background: Sex hormones play a role in both the risk and the prognosis of multiple sclerosis (MS). Considering all stages of women's reproductive life, data regarding the influence of menopause on MS and vice versa are scarce. Objective: The aim of this study was to review the evidence addressing the relationship between menopause and MS. Methods: A literature search through PubMed was conducted, selecting studies that assessed (1) the influence of menopause in the MS course, (2) the influence of MS and disease-modifying drugs (DMD) on the development of menopause and (3) the effect of hormone replacement therapy (HRT) on symptoms of menopausal MS patients. Results: (1) Most studies suggest menopause may transitorily aggravate MS symptoms. Two studies found an inflexion point on the Expanding Disability Status Scale (EDSS) with clinical worsening during the menopausal transition. Another study considering full EDSS trajectories from clinically isolated syndrome to postmenopause did not find such an EDSS inflection; (2) MS and DMD do not seem to alter the age of menopause onset; and (3) HRT in menopausal MS patients has not shown consistent benefits. Conclusion: Menopause seems to be associated with transient symptom worsening, but the existence of an inflection in disability progression is still controversial. Properly designed studies are necessary to achieve conclusive results. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

3. Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop

Author

Amato, Maria Pia, Derfuss, Tobias, Hemmer, Bernard, Liblau, Roland, Montalban, Xavier, Soelberg Sørensen, Per, Miller, David H, Alfredsson, Lars, Aloisi, Francesca, Ascherio, Alberto, Baldin, Elisa, Bjørnevik, Kjetil, Comabella, Manuel, Correale, Jorge, Cortese, Marianna, D’Hooghe, Marie, Ghezzi, Angelo, Gold, Julian, Hellwig, Kerstin, Hemmer, Bernhard, Koch-Henricksen, Nils, Langer Gould, Annette, Linker, Ralf, Lolli, Francesco, Lucas, Robyn, Lünemann, Jan, Magyari, Melinda, Massacesi, Luca, Miller, Ariel, Monteyne, Philippe, Mowry, Ellen, Münz, Christian, Nielsen, Nete M, Olsson, Tomas, Oreja-Guevara, Celia, Otero, Susana, Pugliatti, Maura, Reingold, Stephen, Riise, Trond, Robertson, Neil, Salvetti, Marco, Sidhom, Youssef, Smolders, Joost, Sollid, Ludvig, Steiner, Israel, Stenager, Egon, Sundstrom, Peter, Taylor, Bruce V, Tremlett, Helen, Trojano, Maria, Uccelli, Antonio, Waubant, Emmanuelle, and Wekerle, Hartmut

Subjects
0301 basic medicine, comorbidities, environmental risk factors, infections, lifestyle, multiple sclerosis, vitamin D, neurology, neurology (clinical), medicine.medical_specialty, Disease, 03 medical and health sciences, 0302 clinical medicine, medicine, Demyelinating disease, Vitamin D and neurology, Genetic predisposition, Intensive care medicine, business.industry, Multiple sclerosis, Experimental autoimmune encephalomyelitis, medicine.disease, 3. Good health, risk factor, multiple sclerosis, 030104 developmental biology, Clinical research, Neurology, Etiology, Physical therapy, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Multiple sclerosis (MS) is an inflammatory and neurodegenerative demyelinating disease of the central nervous system (CNS), most likely autoimmune in origin, usually beginning in early adulthood. The aetiology of the disease is not well understood; it is viewed currently as a multifactorial disease which results from complex interactions between genetic predisposition and environmental factors, of which a few are potentially modifiable. Improving our understanding of these factors can lead to new and more effective approaches to patient counselling and, possibly, prevention and management of the disease. The 2016 focused workshop of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) addressed the topic of environmental, modifiable risk factors for MS, gathering experts from around the world, to collate experimental and clinical research into environmental factors that have been associated with the disease onset and, in a few cases, disease activity and progression. A number of factors, including infections, vitamin D deficiency, diet and lifestyle factors, stress and comorbidities, were discussed. The meeting provided a forum to analyse available evidence, to identify inconsistencies and gaps in current knowledge and to suggest avenues for future research.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results