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2 results on '"Piraye Oflazer"'

1. Muscle magnetic resonance imaging in spinal muscular atrophy type 3: Selective and progressive involvement

Author

Hacer, Durmus, Ravza, Yilmaz, Yesim, Gulsen-Parman, Piraye, Oflazer-Serdaroglu, Marina, Cuttini, Memduh, Dursun, and Feza, Deymeer

Subjects
Adult, Male, Muscular Atrophy, Young Adult, Adolescent, Thigh, Disease Progression, Humans, Female, Middle Aged, Spinal Muscular Atrophies of Childhood, Muscle, Skeletal, Magnetic Resonance Imaging
Abstract

In this study we sought to identify magnetic resonance imaging (MRI) signs of selective muscle involvement and disease progression in patients with spinal muscular atrophy type 3b (SMA3b).Twenty-five patients with genetically confirmed SMA3b underwent MRI on a 1.5-Tesla MR scanner.MRI showed significantly more severe involvement of the iliopsoas than of the gluteus maximus muscles, and more severe involvement of the triceps brachii than of the biceps brachii muscles. The quadriceps femoris muscles were severely involved. The deltoid, adductor longus, portions of the hamstrings, gracilis, sartorius, and rectus abdominis muscles were well preserved. We found a significant positive correlation between MRI changes and disease duration for gluteus maximus and triceps brachii. Follow-up MRIs of 4 patients showed disease progression.This study confirms the pattern of selective muscle involvement suggested by previous studies and further refines muscle MRI changes in SMA3b. Progressive muscle involvement is implicated. Muscle Nerve 55: 651-656, 2017.

Published
2016

2. Nerve conduction studies in Charcot-Marie-Tooth disease in a cohort from Turkey

Author

Esra Battaloglu, Zeliha Matur, Yesim Parman, Mürüvvet Poyraz, Feza Deymeer, and Piraye Oflazer-Serdaroglu

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Turkey, Physiology, Neural Conduction, medicine.disease_cause, Nerve conduction velocity, Cohort Studies, Cellular and Molecular Neuroscience, Myelin, Young Adult, Charcot-Marie-Tooth Disease, Physiology (medical), Peripheral myelin protein 22, SH3TC2, medicine, Humans, education, Child, Aged, Mutation, education.field_of_study, business.industry, Electromyography, Myelin protein zero, Anatomy, Middle Aged, medicine.anatomical_structure, Connexin 32, Female, Neurology (clinical), business
Abstract

Introduction: In the demyelinating form of Charcot–Marie–Tooth disease, median motor conduction velocity (MCV) was noted to be around 20 m/s in peripheral myelin protein 22 (PMP22) duplications, in contrast to higher MCVs in connexin 32 gene (Cx32) mutations and lower MCVs in the demyelinating form of myelin protein zero gene (MPZ) mutations. Methods: Nerve conduction studies were performed in 64 families with both common and rare mutations. Results: Mean MCV of the median nerve was 20 ± 5 m/s in PMP22 duplications, 34 ± 6 m/s in Cx32 mutations, 20 ± 9 m/s in KIAA1985 (SH3TC2) mutations, and 11 ± 8 m/s in MPZ mutations. Conduction was generally uniform; however, conduction blocks were present in 1 patient each with the MPZ mutation and PMP22 duplication, both with unusual phenotypes. Conclusion: Our results confirm those of the other investigators. Electrophysiological results of the rare KIAA1985 (SH3TC2) mutation reveal that their MCVs span a broad range and that conduction is uniform. Muscle Nerve, 2011

Published
2010

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