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The molecular pathways regulating post-natal neurogenesis are poorly understood. c-Myb is recognised as maintaining haemopoietic and colonic cells in an undifferentiated state, while CREB is known to be important for neuronal cell survival and function. These properties are important for maintaining a neural progenitor population in adult brain. We review the literature that suggests c-Myb and CREB co-regulate a number of factors involved in neurogenesis. Emerging data is discussed, which shows that c- Myb is required for normal postnatal brain development in the mouse, and we consider how these mice will be used to identify factors co-regulated by c- Myb and CREB, specifically involved in neurogenesis. [ABSTRACT FROM AUTHOR]