1. The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage
- Author
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Sang Wha Lee, Yoo Jin Choi, Su Yeong Seo, Min Ho Jeong, Hyoun Ji Kim, Byung Hyouk Nam, Wol Soon Jo, Jae-Yun Lee, and Jae-Dong Lee
- Subjects
Lipopolysaccharide ,biology ,Traditional medicine ,medicine.drug_class ,Pro-inflammatory cytokines ,Nitric oxide ,Pharmacology ,biology.organism_classification ,RAW 264.7 cell ,Microbiology ,In vitro ,Anti-inflammatory ,Cordyceps militaris ,Proinflammatory cytokine ,chemistry.chemical_compound ,Anti-inflammatory activity ,Infectious Diseases ,chemistry ,medicine ,Macrophage ,Tumor necrosis factor alpha ,Research Article - Abstract
The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-α and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.
- Published
- 2010