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In yeasts truncated YAP1 homologues confer antifungal resistance. Our previous work has identified Af yap1, a YAP1 homologue, in Aspergillus fumigatus and found that it is responsible for oxidative stress in vitro. In order to decipher whether truncated Af yap1 involves in antifungal resistance mechanism and in oxidative stress adaptation in A. fumigatus, we introduce a putatively hyperactive truncated Af yap1 into wild-type A. fumigatus. We found that the resulted A. fumigatus containing truncated Af yap1 attenuated susceptibility to voriconazole and resistance to various oxidants. However, the Af yap1 deletion mutant and the strain harboring multiple copies of full-length Af yap1 had voriconazole susceptibility comparable with that of a wild-type A. fumigatus strain. Our study demonstrates that the truncated Af yap1 may involve in antifungal resistance to voriconazole in A. fumigatus and that the truncated Af yap1 sufficiently confers tolerance to oxidative stress in A. fumigatus. [ABSTRACT FROM AUTHOR]