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32 results on '"Liu, Zhuang"'

22. Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2and Catalase for Enhanced Radio-Immunotherapy of Cancer

Author

Song, Xuejiao, Xu, Jun, Liang, Chao, Chao, Yu, Jin, Qiutong, Wang, Chao, Chen, Meiwan, and Liu, Zhuang

Abstract

The recent years have witnessed the blooming of cancer immunotherapy, as well as their combinational use together with other existing cancer treatment techniques including radiotherapy. However, hypoxia is one of several causes of the immunosuppressive tumor microenvironment (TME). Herein, we develop an innovative strategy to relieve tumor hypoxia by delivering exogenous H2O2into tumors and the subsequent catalase-triggered H2O2decomposition. In our experiment, H2O2and catalase are separately loaded within stealthy liposomes. After intravenous (iv) preinjection of CAT@liposome, another dose of H2O2@liposome is injected 4 h later. The sustainably released H2O2could be decomposed by CAT@liposome, resulting in a long lasting effect in tumor oxygenation enhancement. As the result, the combination treatment by CAT@liposome plus H2O2@liposome offers remarkably enhanced therapeutic effects in cancer radiotherapy as observed in a mouse tumor model as well as a more clinically relevant patient-derived xenograft tumor model. Moreover, the relieved tumor hypoxia would reverse the immunosuppressive TME to favor antitumor immunities, further enhancing the combined radio-immunotherapy with cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade. This work presents a simple yet effective strategy to promote tumor oxygenation via sequential delivering catalase and exogenous H2O2into tumors using well-established liposomal carriers, showing great potential for clinical translation in radio-immunotherapy of cancer.

Published
2018
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23. Bimetallic Oxide MnMoOXNanorods for in Vivo Photoacoustic Imaging of GSH and Tumor-Specific Photothermal Therapy

Author

Gong, Fei, Cheng, Liang, Yang, Nailin, Jin, Qiutong, Tian, Longlong, Wang, Mengyun, Li, Yonggang, and Liu, Zhuang

Abstract

Accurate imaging of glutathione (GSH) in vivo is able to provide real-time visualization of physiological and pathological conditions. Herein, we successfully synthesize bimetallic oxide MnMoOXnanorods as an intelligent nanoprobe for in vivo GSH detection via photoacoustic (PA) imaging. The obtained MnMoOXnanoprobe with no near-infrared (NIR) absorption in the absence of GSH would exhibit strong GSH-responsive NIR absorbance, endowing PA imaging detection of GSH. Due to the up-regulated GSH concentration in the tumor microenvironment, our MnMoOXnanoprobe could be utilized for in vivo tumor-specific PA imaging. Moreover, MnMoOXnanorods with GSH-responsive NIR absorbance could also be employed to achieve tumor-specific photothermal therapy (PTT). Importantly, such MnMoOXnanorods show inherent biodegradability and could be rapidly cleared out from the body, minimizing their long-term body retention and potential toxicity. Our work presents a new type of GSH-responsive nanoprobe based on bimetallic oxide nanostructures, promising for tumor-specific imaging and therapy.

Published
2018
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29. Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H 2 O 2 and Catalase for Enhanced Radio-Immunotherapy of Cancer.

Author

Song X, Xu J, Liang C, Chao Y, Jin Q, Wang C, Chen M, and Liu Z

Subjects
Animals, Catalase chemistry, Catalase immunology, Cell Line, Tumor, Combined Modality Therapy, Humans, Hydrogen Peroxide chemistry, Hydrogen Peroxide immunology, Liposomes administration & dosage, Liposomes immunology, Mice, Neoplasms pathology, Neoplasms therapy, Oxygen chemistry, Oxygen metabolism, Radioimmunotherapy, Tumor Hypoxia immunology, Tumor Microenvironment drug effects, Tumor Microenvironment immunology, Catalase administration & dosage, Hydrogen Peroxide administration & dosage, Neoplasms immunology, Neoplasms radiotherapy
Abstract

The recent years have witnessed the blooming of cancer immunotherapy, as well as their combinational use together with other existing cancer treatment techniques including radiotherapy. However, hypoxia is one of several causes of the immunosuppressive tumor microenvironment (TME). Herein, we develop an innovative strategy to relieve tumor hypoxia by delivering exogenous H 2 O 2 into tumors and the subsequent catalase-triggered H 2 O 2 decomposition. In our experiment, H 2 O 2 and catalase are separately loaded within stealthy liposomes. After intravenous (iv) preinjection of CAT@liposome, another dose of H 2 O 2 @liposome is injected 4 h later. The sustainably released H 2 O 2 could be decomposed by CAT@liposome, resulting in a long lasting effect in tumor oxygenation enhancement. As the result, the combination treatment by CAT@liposome plus H 2 O 2 @liposome offers remarkably enhanced therapeutic effects in cancer radiotherapy as observed in a mouse tumor model as well as a more clinically relevant patient-derived xenograft tumor model. Moreover, the relieved tumor hypoxia would reverse the immunosuppressive TME to favor antitumor immunities, further enhancing the combined radio-immunotherapy with cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade. This work presents a simple yet effective strategy to promote tumor oxygenation via sequential delivering catalase and exogenous H 2 O 2 into tumors using well-established liposomal carriers, showing great potential for clinical translation in radio-immunotherapy of cancer.

Published
2018
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30. Bimetallic Oxide MnMoO X Nanorods for in Vivo Photoacoustic Imaging of GSH and Tumor-Specific Photothermal Therapy.

Author

Gong F, Cheng L, Yang N, Jin Q, Tian L, Wang M, Li Y, and Liu Z

Subjects
Animals, Hyperthermia, Induced methods, Manganese Compounds therapeutic use, Mice, Molybdenum therapeutic use, Nanotubes ultrastructure, Neoplasms therapy, Oxides therapeutic use, Phototherapy methods, Tumor Microenvironment, Glutathione analysis, Manganese Compounds chemistry, Molybdenum chemistry, Nanotubes chemistry, Neoplasms diagnosis, Oxides chemistry, Photoacoustic Techniques methods, Theranostic Nanomedicine methods
Abstract

Accurate imaging of glutathione (GSH) in vivo is able to provide real-time visualization of physiological and pathological conditions. Herein, we successfully synthesize bimetallic oxide MnMoO X nanorods as an intelligent nanoprobe for in vivo GSH detection via photoacoustic (PA) imaging. The obtained MnMoO X nanoprobe with no near-infrared (NIR) absorption in the absence of GSH would exhibit strong GSH-responsive NIR absorbance, endowing PA imaging detection of GSH. Due to the up-regulated GSH concentration in the tumor microenvironment, our MnMoO X nanoprobe could be utilized for in vivo tumor-specific PA imaging. Moreover, MnMoO X nanorods with GSH-responsive NIR absorbance could also be employed to achieve tumor-specific photothermal therapy (PTT). Importantly, such MnMoO X nanorods show inherent biodegradability and could be rapidly cleared out from the body, minimizing their long-term body retention and potential toxicity. Our work presents a new type of GSH-responsive nanoprobe based on bimetallic oxide nanostructures, promising for tumor-specific imaging and therapy.

Published
2018
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31. Janus Iron Oxides @ Semiconducting Polymer Nanoparticle Tracer for Cell Tracking by Magnetic Particle Imaging.

Author

Song G, Chen M, Zhang Y, Cui L, Qu H, Zheng X, Wintermark M, Liu Z, and Rao J

Subjects
Animals, Cell Tracking, HeLa Cells, Humans, Magnetic Resonance Imaging methods, Magnetics methods, Mice, Nanoparticles ultrastructure, Neoplasms diagnostic imaging, Optical Imaging methods, Whole Body Imaging methods, Contrast Media chemistry, Ferric Compounds chemistry, Nanoparticles chemistry, Polymers chemistry, Semiconductors
Abstract

Iron oxides nanoparticles tailored for magnetic particle imaging (MPI) have been synthesized, and their MPI signal intensity is three-times that of commercial MPI contrast (Ferucarbotran, also called Vivotrax) and seven-times that of MRI contrast (Feraheme) at the same Fe concentration. MPI tailored iron oxide nanoparticles were encapsulated with semiconducting polymers to produce Janus nanoparticles that possessed optical and magnetic properties for MPI and fluorescence imaging. Janus particles were applied to cancer cell labeling and in vivo tracking, and as few as 250 cells were imaged by MPI after implantation, corresponding to an amount of 7.8 ng of Fe. Comparison with MRI and fluorescence imaging further demonstrated the advantages of our Janus particles for MPI-super sensitivity, unlimited tissue penetration, and linear quantitativity.

Published
2018
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32. Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice.

Author

de la Zerda A, Liu Z, Bodapati S, Teed R, Vaithilingam S, Khuri-Yakub BT, Chen X, Dai H, and Gambhir SS

Subjects
Acoustics, Animals, Integrins chemistry, Mice, Oligopeptides chemistry, Photochemistry, Nanotubes, Carbon
Abstract

Photoacoustic imaging is an emerging modality that overcomes to a great extent the resolution and depth limitations of optical imaging while maintaining relatively high-contrast. However, since many diseases will not manifest an endogenous photoacoustic contrast, it is essential to develop exogenous photoacoustic contrast agents that can target diseased tissue(s). Here we present a novel photoacoustic contrast agent, Indocyanine Green dye-enhanced single walled carbon nanotube (SWNT-ICG). We conjugated this contrast agent with cyclic Arg-Gly-Asp (RGD) peptides to molecularly target the alpha(v)beta(3) integrins, which are associated with tumor angiogenesis. Intravenous administration of this tumor-targeted contrast agent to tumor-bearing mice showed significantly higher photoacoustic signal in the tumor than in mice injected with the untargeted contrast agent. The new contrast agent gave a markedly 300 times higher photoacoustic contrast in living tissues than previously reported SWNTs, leading to subnanomolar sensitivities. Finally, we show that the new contrast agent can detect approximately 20 times fewer cancer cells than previously reported SWNTs.

Published
2010
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