1. Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent.
- Author
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Krausz AE, Adler BL, Cabral V, Navati M, Doerner J, Charafeddine RA, Chandra D, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, and Friedman AJ
- Subjects
- Animals, Burns therapy, Cell Movement, Dose-Response Relationship, Drug, Drug Delivery Systems, Keratinocytes cytology, Light, Methicillin-Resistant Staphylococcus aureus, Mice, Mice, Inbred BALB C, Microscopy, Electron, Scanning, Nanomedicine methods, Scattering, Radiation, Solubility, Stem Cells, Wound Healing, Zebrafish, Anti-Bacterial Agents administration & dosage, Bacterial Infections drug therapy, Curcumin chemistry, Nanoparticles chemistry
- Abstract
Burn wounds are often complicated by bacterial infection, contributing to morbidity and mortality. Agents commonly used to treat burn wound infection are limited by toxicity, incomplete microbial coverage, inadequate penetration, and rising resistance. Curcumin is a naturally derived substance with innate antimicrobial and wound healing properties. Acting by multiple mechanisms, curcumin is less likely than current antibiotics to select for resistant bacteria. Curcumin's poor aqueous solubility and rapid degradation profile hinder usage; nanoparticle encapsulation overcomes this pitfall and enables extended topical delivery of curcumin. In this study, we synthesized and characterized curcumin nanoparticles (curc-np), which inhibited in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in dose-dependent fashion, and inhibited MRSA growth and enhanced wound healing in an in vivo murine wound model. Curc-np may represent a novel topical antimicrobial and wound healing adjuvant for infected burn wounds and other cutaneous injuries., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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