8 results on '"Hailin Cong"'
Search Results
2. A novel M2Ga2GeO7:N3+ (M = Ca, Ba, Sr; N = Cr, Nd, Er) sub-micron phosphor with multiband NIR emissions: preparation, structure, properties, and LEDs
- Author
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Youqing Shen, Yu Min, Zhihua Li, Bing Yu, Xin Ding, Bin He, and Hailin Cong
- Subjects
Materials science ,Mechanical Engineering ,Doping ,Analytical chemistry ,Bioengineering ,Phosphor ,General Chemistry ,Crystal structure ,medicine.disease_cause ,law.invention ,Tetragonal crystal system ,Mechanics of Materials ,law ,medicine ,General Materials Science ,Electrical and Electronic Engineering ,Penetration depth ,Luminescence ,Ultraviolet ,Light-emitting diode - Abstract
Near-infrared (NIR) emission materials can be widely applied in various fields, such as food detection, imaging, treatment, electronic products. With the trend of miniaturization of equipment, smaller materials are needed. In this work, we successfully synthesized a series of M2Ga2GeO7: N3+ (M = Ca, Ba, Sr; N = Cr, Nd, Er) samples and then focused on the study of Nd3+ doped Sr2Ga2GeO7 (SGGO). A series of SGGO: xNd3+ sub-micron phosphors were prepared via a microwave-assisted sol-gel process combined with subsequent calcination at 750 โ, and the structural information and luminescent properties were systematically studied. SGGO is a representative tetragonal crystal and belonging to the space group of P4(-)21m (113). The Nd3+ ions occupy eight-coordinated Sr2+ sites in the crystal lattice. From SEM analysis, the average particle size distribution is 219.7 ± 41.4 nm. The sub-micron phosphors have rich excitation spectra ranging from 350 nm to 850 nm and can produce multiband NIR emissions of 1331, 1056, and 905 nm when excited by ultraviolet and NIR light. The maximum emission intensity was obtained by optimizing the doping ratio of Nd3+ ions. A commercial chip was then utilized to fabricate light-emitting diodes (LEDs) to verify its application potential in NIR-II mini-LEDs. Compared with blue light LEDs, the as-prepared LEDs had good imaging penetration depth and could be clearly observed under 10 mm of chicken breast coverage. The maximum imaging penetration depth can be 33 mm.
- Published
- 2021
3. Multifunctional Fe
- Author
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Yanhong, Xu, Yuling, Shan, Yixin, Zhang, Bing, Yu, Youqing, Shen, and Hailin, Cong
- Subjects
Drug Carriers ,Microscopy, Confocal ,Cell Survival ,Infrared Rays ,Antineoplastic Agents ,Hydrogen-Ion Concentration ,Magnetic Resonance Imaging ,Carbon ,Ferrosoferric Oxide ,Polyethylene Glycols ,Drug Liberation ,Doxorubicin ,Humans ,Magnetite Nanoparticles ,Metal-Organic Frameworks ,HeLa Cells - Abstract
Multifunctional nanomedicines featuring high drug loading capacity, controllable drug release and real-time self-monitoring are attracting increasing attention due to their potential to improve cancer therapeutic efficacy. Herein, a new kind of Fe
- Published
- 2019
4. Tumor microenvironment-responsive polymer with chlorin e6 to interface hollow mesoporous silica nanoparticles-loaded oxygen supply factor for boosted photodynamic therapy
- Author
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Bing Yu, Hailin Cong, Xue-Mei Wang, Xin Ding, Youqing Shen, and Xiaoming Zhang
- Subjects
Radiation-Sensitizing Agents ,Porphyrins ,Materials science ,Biocompatibility ,Cell Survival ,medicine.medical_treatment ,Breast Neoplasms ,Bioengineering ,Photodynamic therapy ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Mice ,Cell Line, Tumor ,Tumor Microenvironment ,medicine ,Animals ,Humans ,General Materials Science ,Photosensitizer ,Electrical and Electronic Engineering ,Tumor microenvironment ,Chlorophyllides ,Tumor hypoxia ,Mechanical Engineering ,General Chemistry ,Mesoporous silica ,Catalase ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,Combined Modality Therapy ,Glutathione ,Metformin ,0104 chemical sciences ,Oxygen ,Photochemotherapy ,Mechanics of Materials ,Cancer cell ,Biophysics ,Nanoparticles ,Female ,Nanocarriers ,0210 nano-technology ,Porosity - Abstract
Cancer treatment has always been a big problem for people. With the application of photodynamic therapy, the problem has been alleviated. However, the problem of tumor hypoxia affecting photodynamic therapy has been waiting to be resolved. Therefore, we report here that a redox nanocarrier (called RN) is prepared by hollow mesoporous silica sphere (HMSNs) and a redox-responsive polymer ligand. The nanocarrier is loaded with metformin and catalase, and the polymer is linked to the photosensitizer chlorin e6 (Ce6). Metformin inhibits the mitochondrial respiration of cancer cells, reducing the activity of cancer cells and increasing the oxygen concentration required for photodynamic therapy. Not only the effect of photodynamic therapy is enhanced, but also the effect of chemotherapy is increased to achieve super additive treatment. These RNs exhibit not only low cytotoxicity but also high biocompatibility in vitro experiments. In vitro Ce6 release studies have shown a higher release in the presence of glutathione (GSH). Confocal microscopy can further indicate that the nanoparticles are carried to the area around the nucleus of the cancer cells. In addition, treatment with a mouse tumor model demonstrated that RN has an effective therapeutic effect on tumors.
- Published
- 2020
5. Biomedical application of manganese dioxide nanomaterials
- Author
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Bing Yu, Youqing Shen, Hailin Cong, and Yang Chen
- Subjects
Materials science ,Mechanical Engineering ,chemistry.chemical_element ,Tumor therapy ,Bioengineering ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Manganese ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Catalysis ,Nanomaterials ,chemistry ,Mechanics of Materials ,Magnetic imaging ,General Materials Science ,Electrical and Electronic Engineering ,0210 nano-technology ,Biosensor ,Carbon - Abstract
Manganese dioxide nanomaterial is a new type of inorganic nanomaterial offering numerous advantages: simple preparation, low cost, and environmental friendliness. This review summarizes the traditional and novel synthetic methods for manganese dioxide nanomaterials and mainly discusses their potential in biomedical applications. Manganese dioxide nanomaterials are mainly used as drug carriers in tumor therapy. In recent years, the construction of multifunctional nano-platforms using manganese dioxide has gradually improved. The main mechanism is that manganese dioxide nanomaterials can combine with reactive oxygen species in the tumor microenvironment to alleviate tumor hypoxia. Manganese dioxide has also been used to quench fluorescent carbon dots in fluorescent probes. Based on the oxidation ability and catalytic activity of MnO2, MnO2 nanosheets are widely used to build biosensors. New research shows that manganese dioxide nanomaterials also have great potential in gene therapy and nuclear magnetic imaging.
- Published
- 2020
6. Multifunctional Fe3O4@C-based nanoparticles coupling optical/MRI imaging and pH/photothermal controllable drug release as efficient anti-cancer drug delivery platforms
- Author
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Yan-Hong Xu, Hailin Cong, Bing Yu, Youqing Shen, Yixin Zhang, and Shan Yuling
- Subjects
Materials science ,Mechanical Engineering ,Photothermal effect ,Nanoparticle ,Bioengineering ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Photothermal therapy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Imaging agent ,0104 chemical sciences ,Targeted drug delivery ,Mechanics of Materials ,Drug delivery ,PEGylation ,General Materials Science ,Electrical and Electronic Engineering ,0210 nano-technology ,Superparamagnetism - Abstract
Multifunctional nanomedicines featuring high drug loading capacity, controllable drug release and real-time self-monitoring are attracting increasing attention due to their potential to improve cancer therapeutic efficacy. Herein, a new kind of Fe3O4@C-based nanoparticles modified with isoreticular metal organic frameworks (IRMOF-3), folic acid (FA) and detachable polyethylene glycol (PEG) under tumor microenvironment was developed. The core-shell structured Fe3O4@C was synthesized via the one-pot solvothermal reaction and the IRMOF-3 layers were coated on the outer shell of Fe3O4@C through layer-by-layer coating method. The FA and PEG were conjugated on the surface of nanoparticles by reacting with the amine groups provided by IRMOF-3. The as-synthesized nanoparticles showed stable photothermal effect, superparamagnetic properties and blue fluorescence characteristic under 360 nm irradiation. The in vitro experiments showed that the drug loaded nanoparticles exhibit pH-dependent drug release property, and PEGylation was proved effective in suppressing burst drug release (only 8.0% of drugs were released within 95 h). The confocal laser scanning microscopy study revealed that the as-synthesized nanoparticles could serve as a cell imaging agent and the cell internalization can be significantly enhanced after FA modified. The IRMOF-3 modified nanoparticles showed negligible cytotoxicity and the drug loaded nanoparticles showed pH/photothermal-stimuli enhanced cytotoxicity in vitro. It is believed that the present smart drug delivery platforms will hold great potential in imaging guided drug delivery and cancer therapy.
- Published
- 2019
7. Non-adhesive PEG hydrogel nanostructures for self-assembly of highly ordered colloids
- Author
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Hailin Cong, Tingrui Pan, and Alexander Revzin
- Subjects
Nanostructure ,Materials science ,Fabrication ,Biocompatibility ,Mechanical Engineering ,technology, industry, and agriculture ,Bioengineering ,Nanotechnology ,General Chemistry ,Polyethylene glycol ,chemistry.chemical_compound ,Nanolithography ,chemistry ,Mechanics of Materials ,PEG ratio ,Surface modification ,General Materials Science ,Self-assembly ,Electrical and Electronic Engineering - Abstract
In this paper, we report on the effect of patterned non-adhesive hydrogel nanosurfaces on the self-assembly of highly ordered colloids. Polyethylene glycol (PEG) hydrogel is employed as the substrate material in the study, for its desired non-adhesive property, and biocompatibility as well as photopatternability. Ultrafine PEG features are photopatterned onto glass substrates with minimal feature resolution of 500 nm using ultraviolet or deep ultraviolet exposure. By simply controlling the colloidal concentration of the nanoassembly solutions and the dimensions of the wells, a range of highly organized nanocolloidal patterns are formed inside the PEG wells. Unlike the traditional surface modification techniques, ours takes advantage of the unique non-adhesive property of PEG hydrogels to achieve extremely high selectivity in the pattern-assisted nanoassembly. Our experiments show that with oxygen plasma treatment, the non-adhesive property of the PEG surface deteriorates significantly, leading to non-selective assembly with complete surface coverage of nanocolloidal beads under the same processing condition. Therefore, benefiting from the unique non-adhesive surface property, the pattern-assisted nanoassembly method enables a highly predictable and robust process for colloidal nanofabrication, and the obtained nanocolloidal arrays with well organized patterns could potentially find applications in photonic crystal fabrication, biological sensing and analytical detection.
- Published
- 2009
8. Multifunctional Fe3O4@C-based nanoparticles coupling optical/MRI imaging and pH/photothermal controllable drug release as efficient anti-cancer drug delivery platforms.
- Author
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Yanhong Xu, Yuling Shan, Yixin Zhang, Bing Yu, Youqing Shen, and Hailin Cong
- Subjects
ISOINDOLE ,MAGNETIC particle imaging ,NANOPARTICLES - Abstract
Multifunctional nanomedicines featuring high drug loading capacity, controllable drug release and real-time self-monitoring are attracting increasing attention due to their potential to improve cancer therapeutic efficacy. Herein, a new kind of Fe
3 O4 @C-based nanoparticles modified with isoreticular metal organic frameworks (IRMOF-3), folic acid (FA) and detachable polyethylene glycol (PEG) under tumor microenvironment was developed. The core-shell structured Fe3 O4 @C was synthesized via the one-pot solvothermal reaction and the IRMOF-3 layers were coated on the outer shell of Fe3 O4 @C through layer-by-layer coating method. The FA and PEG were conjugated on the surface of nanoparticles by reacting with the amine groups provided by IRMOF-3. The as-synthesized nanoparticles showed stable photothermal effect, superparamagnetic properties and blue fluorescence characteristic under 360 nm irradiation. The in vitro experiments showed that the drug loaded nanoparticles exhibit pH-dependent drug release property, and PEGylation was proved effective in suppressing burst drug release (only 8.0% of drugs were released within 95 h). The confocal laser scanning microscopy study revealed that the as-synthesized nanoparticles could serve as a cell imaging agent and the cell internalization can be significantly enhanced after FA modified. The IRMOF-3 modified nanoparticles showed negligible cytotoxicity and the drug loaded nanoparticles showed pH/photothermal-stimuli enhanced cytotoxicity in vitro. It is believed that the present smart drug delivery platforms will hold great potential in imaging guided drug delivery and cancer therapy. [ABSTRACT FROM AUTHOR]- Published
- 2019
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