7 results on '"Jun Ren"'
Search Results
2. Substituent-mediated quantum interference toward a giant single-molecule conductance variation
- Author
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Wen-Yan Chang, Ya-Hao Wang, Jing-Zhe Chen, Jia-Ying Fu, Xiao-Shun Zhou, Shan Jin, Jun-Ren Huang, Jin-Na Zhang, Yi-Fan Zhou, and Lin-Qi Pei
- Subjects
Materials science ,Mechanical Engineering ,Substituent ,Conductance ,Bioengineering ,General Chemistry ,Nitryl ,Antiresonance ,Molecular physics ,law.invention ,chemistry.chemical_compound ,Nanoelectronics ,chemistry ,Mechanics of Materials ,law ,Molecule ,General Materials Science ,Electrical and Electronic Engineering ,Scanning tunneling microscope ,Break junction - Abstract
Quantum interference (QI) in single molecular junctions shows a promising perspective for realizing conceptual nanoelectronics. However, controlling and modulating the QI remains a big challenge. Herein, two-type substituents at different positions of meta-linked benzene, namely electron-donating methoxy (–OMe) and electron-withdrawing nitryl (–NO2), are designed and synthesized to investigate the substituent effects on QI. The calculated transmission coefficients T(E) indicates that –OMe and –NO2 could remove the antiresonance and destructive quantum interference (DQI)-induced transmission dips at position 2. –OMe could raise the antiresonance energy at position 4 while –NO2 groups removes the DQI features. For substituents at position 5, both of them are nonactive for tuning QI. The conductance measurements by scanning tunneling microscopy break junction show a good agreement with the theoretical prediction. More than two order of magnitude single-molecule conductance on/off ratio could be achieved at the different positions of –NO2 substituent groups at room temperature. The present work proves chemical substituents can be used for tuning QI features in single molecular junctions, which provides a feasible way toward realization of high-performance molecular devices.
- Published
- 2021
3. Mesoporous magnetic hollow nanoparticles-protein carriers for lysosome escaping and cytosolic delivery
- Author
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Yanqi Zhang, Fangqiong Tang, Dong Chen, Xinglu Huang, Linlin Li, Xianwei Meng, Huiyu Liu, and Jun Ren
- Subjects
Materials science ,biology ,Mechanical Engineering ,Nanoparticle ,Bioengineering ,General Chemistry ,Controlled release ,Cytosol ,Membrane ,medicine.anatomical_structure ,Biochemistry ,Mechanics of Materials ,Ionic strength ,Lysosome ,medicine ,biology.protein ,Biophysics ,General Materials Science ,Electrical and Electronic Engineering ,Bovine serum albumin ,Mesoporous material - Abstract
It is important for a controlled release system to determine whether nanoparticles can penetrate cell membranes and deliver protein into the nuclear or cytosolic compartments of cells, and thus function as carriers. Here, we prepared different functionalized mesoporous magnetic hollow nanoparticles (MMHs) and chose bovine serum albumin (BSA) as a model protein to detect the intracellular trafficking of MMHs. The results showed that MMHs modified with amino groups (AMMHs) were efficient in protein loading and that the loading was dependent on the pH, temperature and ionic strength. Furthermore, we found that the AMMHs not only transported BSA into the cells but also released the BSA carried into the nuclear or cytosolic compartments of the cells. In addition, the nanoparticles were biocompatible, and the encapsulation of BSA in AMMHs did not affect their bioactivity. Taken together, AMMHs are excellent carriers for releasing protein into the cytosol and nucleus, and they have the potential to be used in a controlled release system.
- Published
- 2011
4. A study of the electron transfer and photothermal effect of gold nanorods on a glucose biosensor
- Author
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Fangqiong Tang, Liuqing Yang, Jun Ren, Dong Chen, Huiyu Liu, and Xiangling Ren
- Subjects
Materials science ,Photochemistry ,Bioengineering ,Nanotechnology ,macromolecular substances ,Biosensing Techniques ,Nanocomposites ,chemistry.chemical_compound ,Electron transfer ,Glucose Oxidase ,Polyvinyl butyral ,Enzyme Stability ,Electrochemistry ,General Materials Science ,Glucose oxidase ,Electrical and Electronic Engineering ,Platinum ,Nanotubes ,biology ,Mechanical Engineering ,Photothermal effect ,technology, industry, and agriculture ,Electric Conductivity ,Temperature ,General Chemistry ,Surface Plasmon Resonance ,Enzymes, Immobilized ,Glucose ,chemistry ,Mechanics of Materials ,Glutaral ,Electrode ,biology.protein ,Nanorod ,Polyvinyls ,Glutaraldehyde ,Gold ,Biosensor - Abstract
A new glucose biosensor based on the electron transfer and photothermal effect of gold nanorods (GNRs) is reported here. The biosensor was prepared by immobilizing glucose oxidase (GOx) on a platinum (Pt) electrode by a composite film consisting of GNRs, polyvinyl butyral (PVB) and glutaraldehyde. GNRs were synthesized by a gold seed-mediated cetyltrimethylammonium bromide (CTAB) surfactant-assisted approach. The fabrication, characterization and analytical performance of the glucose biosensor based on GNRs are described in this paper. Moreover, the modulation of the biosensor by the photothermal effect based on the unique surface plasma resonance (SPR) property of GNRs was investigated for the first time. The results show that the current response of a glucose biosensor can significantly increase, induced by the electrical conductivity and photothermal effect of GNRs.
- Published
- 2010
5. Magnetic and fluorescent multifunctional chitosan nanoparticles as a smart drug delivery system
- Author
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Xianwei Meng, Yanqi Zhang, Linlin Li, Zhengtao Deng, Dong Chen, Xiangling Ren, Fangqiong Tang, Jun Ren, and Lin Zhang
- Subjects
Materials science ,Mechanical Engineering ,technology, industry, and agriculture ,Bioengineering ,Nanotechnology ,General Chemistry ,Chitosan nanoparticles ,equipment and supplies ,Fluorescent imaging ,Fluorescence ,chemistry.chemical_compound ,chemistry ,Targeted drug delivery ,Mechanics of Materials ,Drug delivery ,Drug release ,General Materials Science ,Glutaraldehyde ,Electrical and Electronic Engineering ,Superparamagnetism - Abstract
An innovative drug delivery system based on magnetic and fluorescent multifunctional chitosan nanoparticles was developed, which combined magnetic targeting, fluorescent imaging and stimulus-responsive drug release properties into one drug delivery system. Water-soluble superparamagnetic Fe3O4 nanoparticles, CdTe quantum dots (QDs) and pharmaceutical drugs were simultaneously incorporated into chitosan nanoparticles; cross-linking the composite particles with glutaraldehyde tailored their size, morphology, surface properties and drug release behaviors. The system showed superparamagnetic and strong fluorescent properties, and was used as a controlled drug release vehicle, which showed pH-sensitive drug release over a long time. The composite magnetic and fluorescent chitosan nanoparticles are potential candidates as a smart drug delivery system.
- Published
- 2007
6. Mesoporous magnetic hollow nanoparticles-protein carriers for lysosome escaping and cytosolic delivery.
- Author
-
Xinglu Huang, Xianwei Meng, Fangqiong Tang, Linlin Li, Dong Chen, Huiyu Liu, Yanqi Zhang, and Jun Ren
- Subjects
CELLS ,OVUM ,PHYSIOLOGY ,ORGANISMS - Abstract
It is important for a controlled release system to determine whether nanoparticles can penetrate cell membranes and deliver protein into the nuclear or cytosolic compartments of cells, and thus function as carriers. Here, we prepared different functionalized mesoporous magnetic hollow nanoparticles (MMHs) and chose bovine serum albumin (BSA) as a model protein to detect the intracellular trafficking of MMHs. The results showed that MMHs modified with amino groups (AMMHs) were efficient in protein loading and that the loading was dependent on the pH, temperature and ionic strength. Furthermore, we found that the AMMHs not only transported BSA into the cells but also released the BSA carried into the nuclear or cytosolic compartments of the cells. In addition, the nanoparticles were biocompatible, and the encapsulation of BSA in AMMHs did not affect their bioactivity. Taken together, AMMHs are excellent carriers for releasing protein into the cytosol and nucleus, and they have the potential to be used in a controlled release system. [ABSTRACT FROM AUTHOR]
- Published
- 2008
7. Magnetic and fluorescent multifunctional chitosan nanoparticles as a smart drug delivery system.
- Author
-
Linlin Li, Dong Chen, Yanqi Zhang, Zhengtao Deng, Xiangling Ren, Xianwei Meng, Fangqiong Tang, Jun Ren, and Lin Zhang
- Subjects
MAGNETICS ,CHITOSAN ,NANOPARTICLES ,DRUG delivery systems - Abstract
An innovative drug delivery system based on magnetic and fluorescent multifunctional chitosan nanoparticles was developed, which combined magnetic targeting, fluorescent imaging and stimulus-responsive drug release properties into one drug delivery system. Water-soluble superparamagnetic Fe3O4 nanoparticles, CdTe quantum dots (QDs) and pharmaceutical drugs were simultaneously incorporated into chitosan nanoparticles; cross-linking the composite particles with glutaraldehyde tailored their size, morphology, surface properties and drug release behaviors. The system showed superparamagnetic and strong fluorescent properties, and was used as a controlled drug release vehicle, which showed pH-sensitive drug release over a long time. The composite magnetic and fluorescent chitosan nanoparticles are potential candidates as a smart drug delivery system. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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