Search

Your search keyword '"Hazard potential"' showing total 4 results
Start Over Descriptor "Hazard potential" Journal nanotoxicology
4 results on '"Hazard potential"'

1. Human hazard potential of nanocellulose: quantitative insights from the literature.

Author

Stoudmann, Natasha, Schmutz, Mélanie, Hirsch, Cordula, Nowack, Bernd, and Som, Claudia

Subjects
*NANOPARTICLE size, *IN vivo studies, *CELL lines, *HAZARDS, *INSIGHT
Abstract

This review aims to elucidate the current knowledge and future research needs regarding the hazard potential of nanocellulose to human health. Growing interest from research and industry alike has led to increasing likelihood of human contact to the material via various exposure routes. Although a number of comprehensive reviews on human health hazards of nanocellulose have been conducted, this paper brings new insights as it systematically analyzes and quantitatively assesses the results of in vivo and in vitro tests in terms of investigated endpoints, tested concentration ranges, physicochemical properties, surface modifications and source of the tested nanocellulose, exposure route, and cell lines used. The quality of the studies is further inspected based on various established criteria. Considering the rapid development of nanocellulose-based products and the novelty of the material, human health studies remain scarce. By assessing those that have been conducted, patterns and gaps were identified that will be helpful to guide future research. The results show that there are still significant uncertainties remaining, particularly regarding in vivo testing, with pulmonary exposure showing some cause for concern. Although a substantial number of in vitro studies have been undertaken, results are often conflicting. The detected effects could not be directly attributed to size of nanoparticles, cell lines, surface modifications or tested concentrations. This may also be linked to the varying quality of the studies. This review ends by identifying key gaps to help pave the way for future research and ensure the safe development and use of nanocellulose. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

2. Human hazard potential of nanocellulose: quantitative insights from the literature

Author

Mélanie Schmutz, Natasha Stoudmann, Cordula Hirsch, Bernd Nowack, and Claudia Som

Subjects
Inhalation Exposure, Surface Properties, Biomedical Engineering, Hazard potential, 02 engineering and technology, Research needs, 010501 environmental sciences, 021001 nanoscience & nanotechnology, Toxicology, 01 natural sciences, Hazardous Substances, 3. Good health, Nanocellulose, Human health, Risk analysis (engineering), Occupational Exposure, Animals, Humans, Nanoparticles, Business, Particle Size, Cellulose, 0210 nano-technology, 0105 earth and related environmental sciences
Abstract

This review aims to elucidate the current knowledge and future research needs regarding the hazard potential of nanocellulose to human health. Growing interest from research and industry alike has led to increasing likelihood of human contact to the material via various exposure routes. Although a number of comprehensive reviews on human health hazards of nanocellulose have been conducted, this paper brings new insights as it systematically analyzes and quantitatively assesses the results of

Published
2020
Full Text
View/download PDF

3. Grouping of nanomaterials to read-across hazard endpoints: a review

Author

Andrew Worth, David Asturiol, Karin Aschberger, Lara Lamon, and Andrea-Nicole Richarz

Subjects
Surface Properties, Biomedical Engineering, 02 engineering and technology, 010501 environmental sciences, Hazard analysis, Toxicology, 01 natural sciences, Risk Assessment, Hazardous Substances, hazard assessment, Grouping, Animals, Humans, REACH regulation, Settore CHIM/12 - Chimica dell'Ambiente e dei Beni Culturali, 0105 earth and related environmental sciences, nanomaterial, read-across, Control banding, Hazard potential, 021001 nanoscience & nanotechnology, Hazard, Nanostructures, Risk analysis (engineering), Solubility, Biological Assay, 0210 nano-technology
Abstract

The use of non-testing strategies like read-across in the hazard assessment of chemicals and nanomaterials (NMs) is deemed essential to perform the safety assessment of all NMs in due time and at lower costs. The identification of physicochemical (PC) properties affecting the hazard potential of NMs is crucial, as it could enable to predict impacts from similar NMs and outcomes of similar assays, reducing the need for experimental (and in particular animal) testing. This manuscript presents a review of approaches and available case studies on the grouping of NMs to read-across hazard endpoints. We include in this review grouping frameworks aimed at identifying hazard classes depending on PC properties, hazard classification modules in control banding (CB) approaches, and computational methods that can be used for grouping for read-across. The existing frameworks and case studies are systematically reported. Relevant nanospecific PC properties taken into account in the reviewed frameworks to support grouping are shape and surface properties (surface chemistry or reactivity) and hazard classes are identified on the basis of biopersistence, morphology, reactivity, and solubility.

Published
2018

4. Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity

Author

Fiona Byrne, Rodger Duffin, Ken Donaldson, Yurii Gounko, Gemma-Louise Davies, Adriele Prina-Mello, Yuri Volkov, Craig A. Poland, J. M. D. Coey, Wan-Seob Cho, and Fiona Murphy

Subjects
Pathology, medicine.medical_specialty, Materials science, Biomedical Engineering, Nanowire, chemistry.chemical_element, 02 engineering and technology, Toxicology, Mice, 03 medical and health sciences, Peritoneal cavity, Nickel, Fibrosis, medicine, Animals, Macrophage, Lung, Peritoneal Cavity, 030304 developmental biology, 0303 health sciences, Nanowires, Hazard potential, 021001 nanoscience & nanotechnology, medicine.disease, Pathogenicity, Mice, Inbred C57BL, medicine.anatomical_structure, chemistry, Lung aspiration, Biophysics, Female, 0210 nano-technology
Abstract

The use of fibre-shaped nanomaterials in commercial applications has met with concern that they could cause health effects similar to those seen with pathogenic fibres such as certain forms of asbestos. Of the attributes which form the fibre pathogenicity paradigm, fibre length is thought to be a critical factor in determining fibre toxicity. We have previously shown that carbon nanotubes display such length-dependent pathogenicity but it remains unclear if other forms of fibrous nanomaterials conform to the fibre pathogenicity paradigm. As such, our aim is to determine the generality of this hypothesis by asking whether a radically different form of fibrous nanomaterial, nickel nanowires, show length-dependent pathogenicity. Our results indicate that nickel nanowires synthesised to be predominantly long (>20 mm) show the ability to elicit strong inflammation in the mouse peritoneal model in a dose-dependent manner; inflammation or fibrosis was not seen with the short (

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results