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Langerhans Cell Histiocytosis (LCH) is a disease of abnormal clonal proliferation of langerhans cell of the bone marrow derived monocyte-macrophage lineage. Cells with characteristic coffee bean/grooved/indented nuclei with a background of histiocytes, lymphocytes, eosinophils and other inflammatory cells are seen. Clinical presentation varies from unifocal unisystem to multifocal unisystem to multifocal multisystem. We present a rare case of multisystem LCH involving high risk organs in a two and a half year old child. presented with the chief complaints of fever and red raised maculopapular lesions on trunk, palm, forehead and scalp for one and a half yrs with hepatosplenomegaly. There were no lytic lesions of the bones. Haematological parameters showed anaemia with thrombocytopenia while Bone Marrow Aspirate showed increase in histiocytic cell with some cells showing characteristic coffee bean, cleaved irregularly contoured nuclei. However, eosinophilia was not seen. Sections from the skin lesions showed cells with similar morphology without usually accompanied eosinophilia. The cells were CD1a and S100 positive. So a FINAL DIAGNOSIS of langerhans cell histiocytosis was made. The emphasis here lies on thorough analysis of the clinical presentations, imaging studies and scrupulous histomorphological and immunohistochemical examination, so that early diagnosis and timely intervention is ensured in such cases where the characteristic features like lytic lesions of bone and eosinophilia is not found.

Introduction: Autopsy is a procedure that helps to study the cause of death. It should be followed by the histopathological examination as it can help in studying the disease process. Aim: To study the prevalence and pattern of lung and liver diseases in medicolegal and neonatal autopsies along with histopathological examination. Materials and Methods: A retrospective descriptive study was carried out to highlight histopathological findings in lung and liver medicolegal and neonatal autopsies. A total of 51 lung and 46 liver autopsy samples were received in the department during the study period. Results: The findings that were observed on histopathological examination of lung were oedema, congestion, bronchopneumonia, emphysema, tubercular pneumonia, meconium aspiration, pulmonary hypoplasia, interstitial pneumonia, type I congenital adenomatoid malformation and fungal pneumonia. The findings seen on the histopathological examination of the liver specimens were sinusoidal and vascular congestion, cirrhosis, steatosis, chronic hepatitis, chronic venous congestion, granulomatous inflammation, adenocarcinoma, portal triaditis and hepatic peliosis. However, there were 14 cases among the lung and liver autopsy cases which showed incidental pathological findings which were not known at the time of death. Conclusion: This study highlights the importance of histopathological report in lung and liver autopsy cases.

Papillary Renal Cell Carcinoma (RCC) is the second most common carcinoma arising from the renal tubular epithelium. It comprises 10-15% of cases in surgical series. The solid variant of papillary RCC includes only those RCCs that lack true papillae but contain the characteristic immunohistochemical and genetic features of papillary RCC. Here, we present the clinical, histopathologic and immunohistochemical findings of a rare case report of solid variant of papillary RCC. A 45 years old female presented with left abdominal mass. Histopathological sections showed tumour cells arranged in tubules, trabeculae and cords with occasional interspersed long branching and angulated channels with pointed ends. Even extensive sampling of the tumour failed to reveal any papille. The differential diagnosis included solid papillary RCC (s-PRCC), Metanephric Adenoma (MA) and Collecting Duct Carcinoma (CDC). Histologically, these tumours may show overlapping features. The use of IHC markers panel comprising of CK7, EMA, Vimentin, AMACAR and WT1 can help to reach at a diagnosis.