1. Two new diterpenoids from the rhizomes of Zingiber officinale
- Author
-
Zhou, Mi, Li, Ting, Zeng, Chen, Pan, Da-bo, Li, Hai-bo, and Yu, Yang
- Subjects
Organic Chemistry ,Plant Science ,Biochemistry ,Analytical Chemistry - Abstract
Two undescribed labdane diterpenoids (5S,8S,9R,10S,11E)-8,17-epoxy-13,14-dinorlabd-11-en-13-one (1) and (5S,9R,10S,12E)-17-hydroxy-labd-7,12-dien-15(16)-olide (2), together with seven known sesquiterpenoids (3���9) and two known monoterpenoids (10���11) were isolated from the dried rhizome of Zingiber officinale. Their structures were elucidated by detailed spectroscopic data (IR, UV, HR-ESI-MS, 1D and 2D NMR), X-ray crystallographic and ECD analysis. Moreover, all the 11 compounds were tested for ��-glucosidase inhibitory effects and 9 was found to exhibit stronger inhibitory effects at IC50 = 4.8 ��M against a positive control acarbose with IC50 = 414.6 ��M.
- Published
- 2022